Goemanne Sophie, Tilmanne Anne, Biarent Dominique, Smeesters Pierre, Simoni Paolo, Mahadeb Bhavna Ansuya, Vicinanza Alfredo
Department of Pediatrics, Hôpital Universitaire des Enfants Reine Fabiola, Université Libre de Bruxelles (ULB), Brussels, Belgium.
Division of Pediatric Infectious Diseases and Infection Prevention and Control, Hôpital Universitaire des Enfants Reine Fabiola, Université Libre de Bruxelles (ULB), Brussels, Belgium.
Front Pediatr. 2022 Oct 13;10:1003708. doi: 10.3389/fped.2022.1003708. eCollection 2022.
is a well-known bacterium associated with carriage and responsible for different types of infections. The Panton-Valentine leucocidin () is a key virulence factor causing tissue necrosis. can, however, be present in both benign and life-threatening infections.
We present three pediatric severe infections occurring over a period of only three weeks, in February 2021, and caused by genetically unrelated methicillin-sensitive producing in a tertiary children's hospital in Belgium. The first one presented with necrotizing pneumonia, the second one with a neck abscess extended to the mediastinum, and the last one had sacral osteomyelitis complicated by endocarditis. The management of these infections is mostly based on expert opinions. The most appropriate treatment seems to be the combination of early surgical drainage of infected collections with an antibiotic regimen associating two antibiotics; beta-lactams and either clindamycin or linezolid. Human immunoglobulins also appear to be useful as adjunctive therapy.
-producing is associated with life-threatening infections in children. Prompt management is needed including surgery and appropriate antibiotic regimens.
是一种与携带相关且可导致不同类型感染的知名细菌。杀白细胞素（PVL）是导致组织坏死的关键毒力因子。然而，在良性感染和危及生命的感染中均可能存在。
我们报告了2021年2月仅三周内发生在比利时一家三级儿童医院的三例儿科严重感染病例，这些感染由基因不相关的产甲氧西林敏感菌引起。第一例表现为坏死性肺炎，第二例为颈部脓肿蔓延至纵隔，最后一例为骶骨骨髓炎并发心内膜炎。这些感染的管理主要基于专家意见。最恰当的治疗似乎是对感染灶进行早期手术引流，并联合使用两种抗生素的抗生素方案；β-内酰胺类抗生素与克林霉素或利奈唑胺联用。人免疫球蛋白似乎也可作为辅助治疗手段。
产PVL的与儿童危及生命的感染相关。需要迅速进行管理，包括手术和适当的抗生素方案。
