Private Clinic Obstetrics and Gynecology, Diyarbakır, Turkey.
Eur Rev Med Pharmacol Sci. 2022 Oct;26(20):7594-7599. doi: 10.26355/eurrev_202210_30034.
The aim of the study was to investigate the existence of neuroendocrine cells and to compare the density of those in normal ovarian tissue, endometriotic and non-endometriotic benign ovarian cysts.
Twenty patients with the diagnosis of endometrioma and 30 control subjects consisting of ovarian serous cystadenoma (n=10), ovarian mucinous cystadenoma (n=10) and normal ovarian tissue (n=10) were included. The tissues were prepared and assessed according to staining density by using the H-score method.
Tissues with mucinous cystadenoma were significantly more stained with PAS and VanGieson, when compared to women with endometrioma. Macrophage deposition was higher in cyst samples with endometrioma and in normal ovarian tissue when compared to serous cystadenoma and mucinous cystadenoma. Normal ovarian tissue was significantly more stained with PGP9.5, NSE and SYN when compared to endometrioma and non-endometriotic benign ovarian cyst. PGP9.5 staining was higher in normal ovarian tissue when compared with endometriotic lesions (p<.001). Endometrioma samples were significantly more stained with p53 when compared to non-endometriotic cysts and normal ovarian tissue. c-Kit staining was mild and not statistically significant among all groups.
During endometrioma transformation, expression intensity of neuroendocrine markers decreases compared to normal ovarian tissue and other benign ovarian cysts.
本研究旨在探讨神经内分泌细胞的存在，并比较正常卵巢组织、子宫内膜异位症和非子宫内膜异位性良性卵巢囊肿中神经内分泌细胞的密度。
纳入 20 例诊断为卵巢子宫内膜异位症患者和 30 例对照组患者，其中包括卵巢浆液性囊腺瘤（n=10）、卵巢黏液性囊腺瘤（n=10）和正常卵巢组织（n=10）。采用 H 评分法评估组织的染色密度。
与卵巢子宫内膜异位症患者相比，黏液性囊腺瘤组织的 PAS 和 VanGieson 染色明显更强烈。与浆液性囊腺瘤和黏液性囊腺瘤相比，子宫内膜异位症和正常卵巢组织的囊液中巨噬细胞沉积更高。与子宫内膜异位症和非子宫内膜异位性良性卵巢囊肿相比，正常卵巢组织的 PGP9.5、NSE 和 SYN 染色明显更强。与子宫内膜异位症病变相比，正常卵巢组织的 PGP9.5 染色更高（p<.001）。与非子宫内膜异位性囊肿和正常卵巢组织相比，子宫内膜异位症样本中 p53 的染色更高。c-Kit 染色在所有组中均较弱，无统计学意义。
在卵巢子宫内膜异位症病变形成过程中，与正常卵巢组织和其他良性卵巢囊肿相比，神经内分泌标志物的表达强度降低。
