Department of Respiratory Medicine, Department of Internal Medicine, Department of Hematology, University Hospital of Patras, Patras, Greece.
Eur Rev Med Pharmacol Sci. 2022 Oct;26(20):7705-7712. doi: 10.26355/eurrev_202210_30047.
Real-life data for vaccination against COVID-19 are sorely needed. This was a population-based analysis aiming at investigating the hospitalization risk for COVID-19 of 98,982 subjects and compare features of vaccinated and unvaccinated patients.
Hospitalized patients with COVID-19 between 01/07/2021 and 11/02/2022 were included in the study.
582 patients were included in the analysis [males: 58.6% (n=341), vaccinated patients: 28.5% (n=166), unvaccinated patients: 71.5% (n=416)]. Median age of vaccinated patients was significantly higher compared to median age of unvaccinated [74.0 (95% CI: 72.0-77.0) vs. 59.0 (95% CI: 57.0-62.0), p=0.0001]. Mean latency time (±SD) from the second dose to hospitalization was 5.7±2.6 months. Between 01/07/2021 and 01/12/2021, unvaccinated subjects had higher risk for hospitalization compared to vaccinated [HR: 2.82, 95% CI: 2.30-3.45, p<0.0001]. Between 02/12/2021 and 11/02/2022, unvaccinated subjects presented with higher risk for hospitalization than subjects that had received booster dose [HR: 2.07, 95% CI: 1.44-2.98, p=0.005], but not than subjects that got two doses. Median value of hospitalization days was higher in unvaccinated patients compared to vaccinated [7.0 (95% CI: 7.0-8.0) vs. 6.0 (95% CI: 5.0-7.0), p=0.02]. Finally, age-adjusted analysis showed that hospitalized unvaccinated patients presented with significantly higher mortality risk compared to hospitalized vaccinated patients [HR: 2.59, 95% CI: 1.69-3.98, p<0.0001].
Vaccination against COVID-19 remains the best way to contain the pandemic. There is an amenable need for booster dose during the omicron era.
迫切需要针对 COVID-19 疫苗接种的真实数据。这是一项基于人群的分析，旨在调查 98982 名受试者感染 COVID-19 的住院风险，并比较接种疫苗和未接种疫苗患者的特征。
本研究纳入了 2021 年 7 月 1 日至 2022 年 2 月 11 日期间因 COVID-19 住院的患者。
共纳入 582 例患者（男性：58.6%（n=341），接种疫苗患者：28.5%（n=166），未接种疫苗患者：71.5%（n=416））。与未接种疫苗患者相比，接种疫苗患者的中位年龄明显更高[74.0（95%CI：72.0-77.0）vs.59.0（95%CI：57.0-62.0），p=0.0001]。从第二剂到住院的平均潜伏期（±SD）为 5.7±2.6 个月。在 2021 年 7 月 1 日至 12 月 1 日期间，与接种疫苗者相比，未接种疫苗者的住院风险更高[HR：2.82，95%CI：2.30-3.45，p<0.0001]。在 2021 年 12 月 2 日至 2022 年 2 月 11 日期间，与接种加强针的患者相比，未接种疫苗者的住院风险更高[HR：2.07，95%CI：1.44-2.98，p=0.005]，但与接种两剂疫苗的患者相比，未接种疫苗者的住院风险并未更高。与接种疫苗者相比，未接种疫苗者的住院天数中位数更高[7.0（95%CI：7.0-8.0）vs.6.0（95%CI：5.0-7.0），p=0.02]。最后，年龄调整分析显示，与接种疫苗的住院患者相比，住院未接种疫苗患者的死亡率风险显著更高[HR：2.59，95%CI：1.69-3.98，p<0.0001]。
接种 COVID-19 疫苗仍然是控制大流行的最佳方法。在奥密克戎时代，需要加强接种。
