Department of Dermatology, University of Maryland School of Medicine, Baltimore, MD.
Department of Dermatology, University of Maryland School of Medicine, Baltimore, MD;
Skinmed. 2022 Oct 31;20(5):387-389. eCollection 2022.
A 54-year-old man presented with worsening bilateral rashes on legs and arms 7 days after receiving his BNT162b2 mRNA COVID-19 (Pfizer) vaccine booster. He developed burning on his palms about 5 days after receiving the booster. On day 6, he observed significant edema on his fingers and palms in addition to thin erythematous papules on his forearms. On day 7, he developed edema on his bilateral dorsal feet, and thin erythematous plaques on his shins. He stated that the rashes were pruritic. He had no rashes following the first two doses of the Pfizer vaccine. He denied having any history of skin disease, autoimmune disease, or allergies. Physical examination revealed multiple thin erythematous papules coalescing into thin plaques on his flexor forearms, and thin erythematous plaques on his dorsal feet (Figure 1). Three 4-mm punch biopsies were performed on his left flexor forearm. The biopsies were carried out at papules present for different lengths of time. Papules at biopsy sites "A," "B," and "C" were present for approximately 24-36 hours, 12-18 hours, and 3-6 hours, respectively (Figure 1).
一位 54 岁男性，在接种 BNT162b2 mRNA COVID-19（辉瑞）疫苗加强针后 7 天，出现双侧腿部和手臂皮疹加重。他在接种加强针后约 5 天出现手掌烧灼感。第 6 天，他观察到手指和手掌明显肿胀，前臂出现细红斑性丘疹。第 7 天，他的双侧脚背出现肿胀，小腿出现细红斑性斑块。他表示皮疹伴有瘙痒。他在前两次接种辉瑞疫苗后没有出现皮疹。他否认有任何皮肤病、自身免疫性疾病或过敏史。体格检查显示他的屈肌前臂多处细红斑性丘疹融合成细斑块，脚背有细红斑性斑块（图 1）。在他的左屈肌前臂进行了 3 次 4mm 打孔活检。活检在不同时间进行，位于丘疹出现的位置。活检部位“A”、“B”和“C”的丘疹分别出现了约 24-36 小时、12-18 小时和 3-6 小时（图 1）。
