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2022年在一个非流行国家爆发的人类猴痘病毒感染相关的组织学特征

Histological Features Associated With Human Mpox Virus Infection in 2022 Outbreak in a Nonendemic Country.

作者信息

Chalali Faris, Merlant Marie, Truong Audrey, Ghosn Jade, Phung Bao-Chau, Mollo Bastien, Perrineau Ségolène, Rahi Mayda, Fidouh-Houhou Nadhira, Ferré Valentine Marie, Brunet-Possenti Florence, Descamps Vincent, Bouscarat Fabrice, Yazdanpanah Yazdan, Deschamps Lydia, Bertin Chloé

机构信息

Dermatology Department, AP-HP, Bichat-Claude Bernard Hospital, University of Paris, Paris, France.

Pathology Department, AP-HP, Bichat-Claude Bernard Hospital, University of Paris, Paris, France.

出版信息

Clin Infect Dis. 2023 Mar 21;76(6):1132-1135. doi: 10.1093/cid/ciac856.

Abstract

Skin histology of papules and pustules from 5 men having sex with men with mpox infection showed viral intracytoplasmic cytopathic changes, interface dermatitis, marked inflammatory dermic infiltrate including superficial neutrophils and perivascular and periadnexal deep lymphocytes. Histologic description of mpox lesions improves our understanding about clinical presentations and may have some therapeutic implications.

摘要

对5名感染猴痘的男男性行为者的丘疹和脓疱进行皮肤组织学检查,结果显示病毒胞质内细胞病变、界面性皮炎、显著的炎症性真皮浸润,包括浅表中性粒细胞以及血管周围和腺周深层淋巴细胞。猴痘病变的组织学描述有助于我们更好地理解临床表现,可能还具有一定的治疗意义。

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