孕期猴痘感染
Mpox (Monkeypox) Infection During Pregnancy.
作者信息
Sampson Mindy M, Magee Gray, Schrader Evan A, Dantuluri Keerti L, Bukhari Areej, Passaretti Catherine, Temming Lorene, Leonard Michael, Philips Jennifer B, Weinrib David
机构信息
Department of Internal Medicine, the Department of Obstetrics and Gynecology, and the Division of Infectious Diseases, Department of Pediatrics, Levine Children's Hospital, Atrium Health, Charlotte, and the Section on Infectious Diseases, Department of Internal Medicine, the Department of Pediatrics, and the Department of Obstetrics and Gynecology, Wake Forest University School of Medicine, Winston-Salem, North Carolina.
出版信息
Obstet Gynecol. 2023 May 1;141(5):1007-1010. doi: 10.1097/AOG.0000000000005170. Epub 2023 Mar 15.
BACKGROUND
An mpox (formerly "monkeypox") outbreak began in 2022, leading to infection in special populations, including pregnant individuals.
CASE
We present a case of an individual who presented with a labial ulcer and subsequent papular rash at 31 weeks of gestation. She was diagnosed with mpox infection and was treated with tecovirimat. She had an uncomplicated induction of labor at 39 2/7 weeks of gestation and delivered a healthy neonate. The neonate had a positive immunoglobulin G test result for orthopoxvirus but did not have skin lesions or positive molecular test results suggestive of infection.
CONCLUSION
Transplacental transmission of mpox is possible, but, in this case, the neonate did not have clinical findings suggestive of active or antenatal mpox infection. Treatment with tecovirimat in gestational cases of mpox may be beneficial.
背景
2022年开始出现猴痘（原称“猴天花”）疫情，导致包括孕妇在内的特殊人群感染。
病例
我们报告一例病例，该患者在妊娠31周时出现唇部溃疡，随后出现丘疹性皮疹。她被诊断为猴痘感染，并接受了特考韦瑞治疗。她在妊娠39又2/7周时顺利引产，产下一名健康的新生儿。新生儿正痘病毒免疫球蛋白G检测结果呈阳性，但没有皮肤病变或提示感染的阳性分子检测结果。
结论
猴痘可能发生经胎盘传播，但在本病例中，新生儿没有提示活动性或产前猴痘感染的临床发现。在妊娠猴痘病例中使用特考韦瑞治疗可能有益。
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