Lyu D, Lan B, Sun X Y, Yang M, Zhang L, Ma F
Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Department of Medical Oncology, Cancer Hospital of Huanxing Chaoyang District, Beijing 100122, China.
Zhonghua Zhong Liu Za Zhi. 2022 Oct 23;44(10):1119-1124. doi: 10.3760/cma.j.cn112152-20210412-00308.
To explore the dynamic changes of Distress Thermometer scores and the relationship between psychological distress and quality of life in Chinese early breast cancer patients during chemotherapy. This prospective study enrolled 110 Chinese postoperative early breast cancer patients between March 2019 and December 2019. The psychological distress and quality of life (QOL) of patients were assessed by using the psychological distress management screening tool and the patient quality of life scale. Logistic regression model was used to analyze the influencing factors of psychological distress degree. The correlation between distress thermometer (DT) score changes and quality of life was analyzed by Pearson correlation analysis. In total, 96 valid cases were analyzed. Before chemotherapy, 47 cases (49.0%) had DT score ≥4 points. After 2 cycles of chemotherapy, 40 cases (41.7%) had DT score ≥4 points. Thirty-four patients (35.4%) had DT score ≥4 points after chemotherapy. The DT score after chemotherapy was lower than that before chemotherapy and after 2 cycles of chemotherapy. Univariate analysis showed that income level and pathological stage were still significant related to the detection of DT score ≥4 points after chemotherapy (<0.05). The changes of DT scores before and after chemotherapy were negatively correlated with the changes of quality of life ( =-0.298, =0.003). The detection rate of psychological distress in patients with early breast cancer during chemotherapy showed a decreasing trend. Income level and tumor stage are significant factors affecting the psychological distress of patients. There is a significant correlation between the psychological distress and the quality of life during chemotherapy. We should pay attention to the evaluation and monitoring state of psychological distress of patients during chemotherapy.
探讨中国早期乳腺癌患者化疗期间苦恼温度计评分的动态变化以及心理困扰与生活质量之间的关系。这项前瞻性研究纳入了2019年3月至2019年12月期间110例中国术后早期乳腺癌患者。采用心理困扰管理筛查工具和患者生活质量量表对患者的心理困扰和生活质量进行评估。采用Logistic回归模型分析心理困扰程度的影响因素。通过Pearson相关分析分析苦恼温度计（DT）评分变化与生活质量之间的相关性。共分析96例有效病例。化疗前，47例（49.0%）DT评分≥4分。化疗2周期后，40例（41.7%）DT评分≥4分。化疗后34例（35.4%）DT评分≥4分。化疗后的DT评分低于化疗前及化疗2周期后。单因素分析显示，收入水平和病理分期仍与化疗后DT评分≥4分的检出显著相关（<0.05）。化疗前后DT评分的变化与生活质量的变化呈负相关（=-0.298，=0.003）。早期乳腺癌患者化疗期间心理困扰的检出率呈下降趋势。收入水平和肿瘤分期是影响患者心理困扰的重要因素。化疗期间心理困扰与生活质量之间存在显著相关性。我们应关注患者化疗期间心理困扰的评估和监测状况。
