Yamauchi N, Watanabe N, Ohtsuka Y, Sone H, Neda H, Maeda M, Niitsu Y, Urushizaki I
Gan To Kagaku Ryoho. 1987 Sep;14(9):2730-4.
The synergistic effect of human recombinant TNF in combination with various anti-cancer drugs was examined in vitro. In vitro treatment of L-M cells with TNF and mitomycin C (MMC), adriamycin (ADM), cytosine arabinoside (Ara-C), actinomycin D (ACD), daunorubicin (DM), cisplatin (CDDP), vincristine (VCR), or 5-fluorouracil (5-FU) revealed a synergistic cytotoxicity. However, the combination of TNF with bleomycin (BLM) failed to show such a synergistic effect.