Yamauchi N, Watanabe N, Ohtsuka Y, Sone H, Neda H, Maeda M, Niitsu Y, Urushizaki I
Gan To Kagaku Ryoho. 1987 Sep;14(9):2730-4.
The synergistic effect of human recombinant TNF in combination with various anti-cancer drugs was examined in vitro. In vitro treatment of L-M cells with TNF and mitomycin C (MMC), adriamycin (ADM), cytosine arabinoside (Ara-C), actinomycin D (ACD), daunorubicin (DM), cisplatin (CDDP), vincristine (VCR), or 5-fluorouracil (5-FU) revealed a synergistic cytotoxicity. However, the combination of TNF with bleomycin (BLM) failed to show such a synergistic effect.
在体外研究了人重组肿瘤坏死因子（TNF）与各种抗癌药物联合使用的协同效应。用TNF与丝裂霉素C（MMC）、阿霉素（ADM）、阿糖胞苷（Ara-C）、放线菌素D（ACD）、柔红霉素（DM）、顺铂（CDDP）、长春新碱（VCR）或5-氟尿嘧啶（5-FU）对L-M细胞进行体外处理，结果显示出协同细胞毒性。然而，TNF与博来霉素（BLM）联合使用未显示出这种协同效应。
