Department of Neurology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Department of Neurology, Minhang Hospital, Fudan University, Shanghai, China.
Int J Rheum Dis. 2022 Nov;25(11):1339-1342. doi: 10.1111/1756-185X.14427. Epub 2022 Aug 27.
Systemic sclerosis (SSc) is a chronic autoimmune disease characterized by microangiopathy, extensive fibrosis and autoantibody production. It is generally believed that microvascular disease is the hallmark of SSc. Macrovascular involvement is not initially considered as a feature of SSc, but its mortality is high, which should not be ignored. Up to the present, SSc patients with cerebral involvement and multiple macrovascular stenosis have been rarely described. We herein report a case of cerebral infarction and severe stenosis of the internal carotid artery and coronary artery associated with SSc.
系统性硬化症（SSc）是一种慢性自身免疫性疾病，其特征为微血管病变、广泛纤维化和自身抗体产生。普遍认为微血管病变是 SSc 的标志。大动脉受累最初不被认为是 SSc 的特征，但它的死亡率很高，不容忽视。到目前为止，很少有报道称 SSc 患者伴有脑实质受累和多处大血管狭窄。本文报告了一例与 SSc 相关的脑梗死和颈内动脉及冠状动脉严重狭窄病例。
