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具有增强生物活性、药代动力学和抗肿瘤功效的干扰素自融合连接体。

Self-fused concatenation of interferon with enhanced bioactivity, pharmacokinetics and antitumor efficacy.

作者信息

Hu Jin, Shi Jianquan, Yuan Yeshuang, Li Shengjie, Zhang Bo, Dong Haitao, Zhong Qing, Xie Qiu, Bai Xiaoyin, Li Yingxing

机构信息

Department of Medical Research Center, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College Beijing 100730 China

Department of Intensive Care Unit, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute Beijing 101149 China.

出版信息

RSC Adv. 2022 Oct 4;12(43):28279-28282. doi: 10.1039/d2ra04978c. eCollection 2022 Sep 28.

DOI:10.1039/d2ra04978c
PMID:36320276
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9531251/
Abstract

We report an easy but universal protein modification approach, self-fused concatenation (SEC), to biosynthesize a set of interferon (IFN) concatemers with improved bioactivity, pharmacokinetics and therapeutic efficacy over the monomeric IFN, and the results can be positively enhanced by the concatenated number of self-fused proteins.

摘要

我们报告了一种简便但通用的蛋白质修饰方法——自融合串联（SEC），用于生物合成一组干扰素（IFN）串联体，这些串联体相较于单体IFN具有更高的生物活性、更好的药代动力学和治疗效果，且自融合蛋白质的串联数量可使结果得到进一步提升。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6489/9531251/124eddebb9ef/d2ra04978c-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6489/9531251/d34610c8b3f9/d2ra04978c-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6489/9531251/87cd0e40af82/d2ra04978c-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6489/9531251/bd338a269e4a/d2ra04978c-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6489/9531251/124eddebb9ef/d2ra04978c-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6489/9531251/d34610c8b3f9/d2ra04978c-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6489/9531251/87cd0e40af82/d2ra04978c-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6489/9531251/bd338a269e4a/d2ra04978c-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6489/9531251/124eddebb9ef/d2ra04978c-f4.jpg

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Biochem Biophys Rep. 2021 Aug 24;28:101112. doi: 10.1016/j.bbrep.2021.101112. eCollection 2021 Dec.
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