Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore, Tamil Nadu, India.
Department of Biotechnology, Jamal Mohammed College, Tiruchirapalli, Tamil Nadu, India.
J Renin Angiotensin Aldosterone Syst. 2022 Oct 17;2022:2238320. doi: 10.1155/2022/2238320. eCollection 2022.
Anemia is one of the predominant hematological conditions, whereas chronic obstructive pulmonary disease (COPD) is a predominant respiratory disease. These two diseases were found to be interlinked, but the physiological pathways are still unclear.
The current study has been aimed at analysing the genetic interrelationship between anemia and COPD in accordance with different altitudes. . The genetic analysis was performed in the gene of anemia, COPD, and healthy individuals for the analysis of single nucleotide polymorphism at rs28949274 and rs17580 locations. . The single nucleotide polymorphism at the locations rs28949274 and rs17580 was present in both anemic and COPD patients. The COPD patients were more prone to mutations (63% had rs28949274, and 11% had rs17580 polymorphisms) than the anemic patients (40% had rs28949274, and 1% had rs17580 polymorphisms). On the basis of altitude, high-altitude individuals were found to be more susceptible to both the polymorphisms.
Based on the current findings, we suggest that the gene has a positive correlation with anemia as well as COPD, and the increase in altitude also influences the diseased conditions in a positive manner.
贫血是最常见的血液学疾病之一，而慢性阻塞性肺疾病（COPD）是最常见的呼吸系统疾病。这两种疾病被发现存在关联，但生理途径尚不清楚。
本研究旨在根据不同海拔分析贫血和 COPD 之间的遗传相互关系。对贫血、COPD 和健康个体的 基因进行单核苷酸多态性 rs28949274 和 rs17580 位点的遗传分析。在 rs28949274 和 rs17580 位置存在单核苷酸多态性，贫血和 COPD 患者均存在。COPD 患者比贫血患者更容易发生突变（63%有 rs28949274 突变，11%有 rs17580 突变）（40%有 rs28949274 突变，1%有 rs17580 突变）。基于海拔，发现高海拔个体更容易受到这两种多态性的影响。
根据目前的研究结果，我们认为 基因与贫血和 COPD 呈正相关，海拔的升高也以积极的方式影响疾病状况。
