中国云南省出现1例输入性新冠病毒奥密克戎变异株BA.2.75感染病例。
An imported human case with the SARS-CoV-2 Omicron subvariant BA.2.75 in Yunnan Province, China.
作者信息
Zhang Meiling, Chen Zhixiao, Zhou Jienan, Zhao Xiaonan, Chen Yaoyao, Sun Yanhong, Liu Zhaosheng, Gu Wenpeng, Luo Chunrui, Fu Xiaoqing, Zhao Xiang
机构信息
Yunnan Center for Disease Control and Prevention, Kunming 650022, China.
National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
出版信息
Biosaf Health. 2022 Dec;4(6):406-409. doi: 10.1016/j.bsheal.2022.10.003. Epub 2022 Oct 28.
The Omicron variants spread rapidly worldwide after being initially detected in South Africa in November 2021. It showed increased transmissibility and immune evasion with far more amino acid mutations in the spike (S) protein than the previously circulating variants of concern (VOCs). Notably, on 15 July 2022, we monitored the first VOC / Omicron subvariant BA.2.75 in China from an imported case. Moreover, nowadays, this subvariant still is predominant in India. It has nine additional mutations in the S protein compared to BA.2, three of which (W152R, G446S, and R493Q reversion) might contribute to higher transmissibility and immune escape. This subvariant could cause wider spread and pose a threat to the global situation. Our timely reporting and continuous genomic analysis are essential to fully elucidate the characteristics of the subvariant BA.2.75 in the future.
2021年11月在南非首次发现后，奥密克戎变种在全球迅速传播。它表现出更强的传播性和免疫逃逸能力，其刺突（S）蛋白中的氨基酸突变远比之前流行的关注变种（VOC）多。值得注意的是，2022年7月15日，我们从一例输入病例中监测到中国首例VOC/奥密克戎亚型BA.2.75。此外，如今该亚型在印度仍然占主导地位。与BA.2相比，它的S蛋白还有另外九个突变，其中三个（W152R、G446S和R493Q回复突变）可能导致更高的传播性和免疫逃逸。该亚型可能导致更广泛传播，对全球局势构成威胁。我们的及时报告和持续的基因组分析对于未来全面阐明BA.2.75亚型的特征至关重要。
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