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用于腈类化合物普遍和选择性加氢制胺的稳定且可重复使用的镍基纳米颗粒。

Stable and reusable Ni-based nanoparticles for general and selective hydrogenation of nitriles to amines.

作者信息

Ma Zhuang, Chandrashekhar Vishwas G, Zhou Bei, Alenad Asma M, Rockstroh Nils, Bartling Stephan, Beller Matthias, Jagadeesh Rajenahally V

机构信息

Leibniz-Institut für Katalyse e.V. Albert-Einstein-Str. 29a Rostock D-18059 Germany

Chemistry Department, College of Science, Jouf University P.O. Box: 2014 Sakaka Saudi Arabia.

出版信息

Chem Sci. 2022 Sep 2;13(36):10914-10922. doi: 10.1039/d2sc02961h. eCollection 2022 Sep 21.

DOI:10.1039/d2sc02961h
PMID:36320707
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9491304/
Abstract

Silica supported ultrasmall Ni-nanoparticles allow for general and selective hydrogenation of all kinds of nitriles to primary amines under mild conditions. By calcination of a template material generated from Ni(ii)nitrate and colloidal silica under air and subsequent reduction in the presence of molecular hydrogen the optimal catalyst is prepared. The prepared supported nanoparticles are stable, can be conveniently used and easily recycled. The applicability of the optimal catalyst material is shown by hydrogenation of >110 diverse aliphatic and aromatic nitriles including functionalized and industrially relevant substrates. Challenging heterocyclic nitriles, specifically cyanopyridines, provided the corresponding primary amines in good to excellent yields. The resulting amines serve as important precursors and intermediates for the preparation of numerous life science products and polymers.

摘要

二氧化硅负载的超小镍纳米颗粒能够在温和条件下将各类腈普遍且选择性地氢化为伯胺。通过在空气中煅烧由硝酸镍和胶体二氧化硅生成的模板材料，并随后在分子氢存在下进行还原，制备出了最优催化剂。所制备的负载型纳米颗粒稳定，使用方便且易于回收。通过对110多种不同的脂肪族和芳香族腈（包括功能化和工业相关底物）进行氢化反应，展示了最优催化剂材料的适用性。具有挑战性的杂环腈，特别是氰基吡啶，能以良好至优异的产率提供相应的伯胺。所得的胺是制备众多生命科学产品和聚合物的重要前体和中间体。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67f5/9491304/7949a02ccf50/d2sc02961h-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67f5/9491304/7e25b59173bd/d2sc02961h-f1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67f5/9491304/1d45d6f5180c/d2sc02961h-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67f5/9491304/f57fd57d0a46/d2sc02961h-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67f5/9491304/9edba38a2421/d2sc02961h-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67f5/9491304/dd662a6f22b7/d2sc02961h-s4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67f5/9491304/7949a02ccf50/d2sc02961h-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67f5/9491304/7e25b59173bd/d2sc02961h-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67f5/9491304/ec5f612c0391/d2sc02961h-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67f5/9491304/5b773a1344e3/d2sc02961h-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67f5/9491304/c4705db44108/d2sc02961h-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67f5/9491304/1d45d6f5180c/d2sc02961h-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67f5/9491304/f57fd57d0a46/d2sc02961h-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67f5/9491304/9edba38a2421/d2sc02961h-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67f5/9491304/dd662a6f22b7/d2sc02961h-s4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67f5/9491304/7949a02ccf50/d2sc02961h-f5.jpg

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