Walsh B T, Lo E S, Cooper T, Lindy D C, Roose S P, Gladis M, Glassman A H
Arch Gen Psychiatry. 1987 Sep;44(9):797-800. doi: 10.1001/archpsyc.1987.01800210041007.
A 1-mg dexamethasone suppression test (DST) was carried out in 66 women with bulimia and in 26 age- and sex-matched controls. Blood samples were obtained at 4 PM on the day following dexamethasone ingestion, and levels of cortisol and of dexamethasone in the plasma were measured. Thirty-two percent of the patients vs only 7% of the controls had plasma cortisol levels of 140 nmol/L (5 micrograms/dL) or greater following the DST (a positive DST). The plasma levels of dexamethasone varied substantially, and there was a significant inverse relationship between the plasma level of cortisol and that of dexamethasone. Patients with positive DST results had lower levels of plasma dexamethasone than did those with negative DST results, and the mean plasma level of dexamethasone was lower in the bulimic group than in the control group. These results suggest that factors other than a disturbance of hypothalamic-pituitary-adrenal activity may contribute to positive DST results in bulimia.
对66名贪食症女性患者以及26名年龄和性别匹配的对照者进行了1毫克地塞米松抑制试验（DST）。在摄入地塞米松后的次日下午4点采集血样，测定血浆中皮质醇和地塞米松的水平。DST后，32%的患者血浆皮质醇水平达到140纳摩尔/升（5微克/分升）或更高，而对照组中这一比例仅为7%（DST结果为阳性）。地塞米松的血浆水平差异很大，并且皮质醇血浆水平与地塞米松血浆水平之间存在显著的负相关关系。DST结果为阳性的患者血浆地塞米松水平低于结果为阴性的患者，并且贪食症组的地塞米松平均血浆水平低于对照组。这些结果表明，除下丘脑 - 垂体 - 肾上腺活动紊乱之外的因素可能导致贪食症患者DST结果呈阳性。
