Curtin Water Quality Research Centre, Curtin University, Perth, WA, Australia.
ChemCentre, Perth, WA, Australia; School of Science, Edith Cowan University, 100 Joondalup Drive, Joondalup, WA 6027, Australia.
J Chromatogr A. 2022 Dec 6;1685:463562. doi: 10.1016/j.chroma.2022.463562. Epub 2022 Oct 14.
A direct injection liquid chromatography-tandem mass spectrometry method was successfully developed for the analysis of 19 illicit drugs and psychopharmaceuticals in raw and treated wastewater. The method includes the analysis of stimulants and opioids, and antidepressant, antipsychotic, antianxiety, appetite suppressant and hallucinogen drugs. The method limits of quantification range from 5 - 59 ng L and 2 - 38 ng L in raw and treated wastewater, respectively. Analysis of raw and treated wastewater samples collected daily for a week from a wastewater treatment plant operating with oxidation ditch technology showed that codeine and tramadol were the drugs with the highest median mass concentrations in raw wastewater (1800 and 1000 ng L, respectively). The presence of some of the drugs in treated wastewater samples implies incomplete removal of illicit drugs and psychopharmaceuticals during wastewater treatment. This method offers an alternative to existing methods for faster screening of wastewater samples without the need for sample pre-concentration techniques, such as solid-phase extraction, with limits of detection in the low nanogram per litre range.
建立了一种直接注射液相色谱-串联质谱法，用于分析未经处理和处理后的废水中的 19 种非法药物和精神药物。该方法包括兴奋剂和阿片类药物、以及抗抑郁药、抗精神病药、抗焦虑药、食欲抑制剂和致幻剂的分析。方法的定量限范围分别为未经处理和处理后的废水中 5-59ng/L 和 2-38ng/L。从采用氧化沟技术运行的污水处理厂每周采集的未经处理和处理后的废水样品进行分析，结果表明，在未经处理的废水中，可待因和曲马多是含量最高的药物（分别为 1800 和 1000ng/L）。在处理后的废水样品中存在一些药物，这意味着在废水处理过程中，非法药物和精神药物的去除并不完全。与现有的方法相比，该方法无需固相萃取等样品浓缩技术，可替代现有的方法，用于更快地筛选废水样品，检测限在纳克每升的低水平范围内。
