子痫前期及其与病理性脑老化的关系。
Preeclampsia and its relationship to pathological brain aging.
作者信息
Testo Abigail A, McBride Carole, Bernstein Ira M, Dumas Julie A
机构信息
Neuroscience Graduate Program, University of Vermont, Burlington, VT, United States.
Department of Obstetrics, Gynecology and Reproductive Sciences, University of Vermont, Burlington, VT, United States.
出版信息
Front Physiol. 2022 Oct 17;13:979547. doi: 10.3389/fphys.2022.979547. eCollection 2022.
The development of preeclampsia during pregnancy may have long-term effects on brain aging in women. Associations between preeclampsia and vascular dementia have been established, however the connection between preeclampsia and Alzheimer's disease has not been as thoroughly explored. Both preeclampsia and Alzheimer's disease have been associated with misfolded amyloid beta proteins and inflammation; due to these similarities, in this minireview, we examined the potential links between a history of preeclampsia and the development of dementia. We also discussed how hypertensive disorders of pregnancy may relate to both normal brain aging and dementia to highlight the need for additional research regarding the long-term cognitive effects of preeclampsia on the brain.
孕期子痫前期的发生可能会对女性大脑衰老产生长期影响。子痫前期与血管性痴呆之间的关联已经确立，然而子痫前期与阿尔茨海默病之间的联系尚未得到充分研究。子痫前期和阿尔茨海默病都与错误折叠的β淀粉样蛋白及炎症有关；鉴于这些相似之处，在本综述中，我们研究了子痫前期病史与痴呆症发展之间的潜在联系。我们还讨论了妊娠期高血压疾病可能与正常脑衰老及痴呆症之间的关系，以强调有必要针对子痫前期对大脑的长期认知影响开展更多研究。
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