Kenner T
Basic Res Cardiol. 1987 May-Jun;82(3):209-15. doi: 10.1007/BF01906851.
In this issue of Basic Research in Cardiology a paper by Timisjärvi et al. is presented in which the problem of afterload, generated by the resistance against which the left ventricle is ejecting, is discussed. These authors have performed experiments in which they examine the role and validity of the so-called mean outflow resistance (MOR) of the left ventricle. In this editorial, the opportunity is taken to present some thoughts on the different possibilities of expressing the interrelation between the heart and the arterial system. It is intended to show how, from the first ideas about ventricular-arterial interaction bei Ph. Broemser (1935; 1) different concepts about simple descriptions of the functioning of the heart, the arterial system and the matching between both have evolved. In particular, the concept by Sunagawa et al. seems worthy of mention. An examination of this, and several other concepts, prove that the peripheral resistance and, particularly, the MOR, are important parameters that determine the influence of the arterial system on the performance of the heart. However, since MOR by definition is closely related to the total peripheral resistance, there is no essential need to introduce this resistance as a new concept of ventricular afterload. Calculations based on this definition of MOR demonstrate an agreement between theory and experimental results.
在本期《心脏病学基础研究》中，呈现了蒂米斯耶尔维等人撰写的一篇论文，文中讨论了左心室射血所对抗的阻力产生的后负荷问题。这些作者进行了实验，研究左心室所谓平均流出阻力（MOR）的作用和有效性。在这篇社论中，借此机会就表达心脏与动脉系统之间相互关系的不同可能性提出一些想法。旨在展示从菲利普·布勒姆瑟（1935年；1）关于心室 - 动脉相互作用的最初想法开始，关于心脏功能、动脉系统以及两者匹配的简单描述的不同概念是如何演变的。特别是，船川等人的概念似乎值得一提。对这一概念以及其他几个概念的研究表明，外周阻力，尤其是MOR，是决定动脉系统对心脏性能影响的重要参数。然而，由于根据定义MOR与总外周阻力密切相关，因此没有必要将这种阻力作为心室后负荷的新概念引入。基于MOR这一定义的计算表明理论与实验结果相符。
