Zhao Shi-Bo, Ma Han-Jun, Wu Zhong-Gang, Ling Bo, Ye Guang-Bin
School of Clinical Medicine,Youjiang Medical University for Nationalities,Baise,Guangxi 533000,China.
School of Pharmacy,Youjiang Medical University for Nationalities,Baise,Guangxi 533000,China.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2022 Oct;44(5):863-867. doi: 10.3881/j.issn.1000-503X.14126.
Pleckstrin homology like domain family A member 1(PHLDA1) is also known as T-cell death-associated gene 51 (TDAG51).Studies have demonstrated that the abnormal expression of PHLDA1 is closely associated with the formation,development,and metastasis of tumors.We summarized the latest research advances in the structure and biological properties of PHLDA1,as well as the roles of PHLDA1 in multiple malignanttumors such as breast cancer,cancer,liver gastric cancer,liver cancer,melanoma,and osteosarcoma,aiming to comprehensively reveal the significance of PHLDA1 in the clinical diagnosis of tumors.
普列克底物蛋白同源结构域样家族A成员1（PHLDA1）也被称为T细胞死亡相关基因51（TDAG51）。研究表明，PHLDA1的异常表达与肿瘤的形成、发展和转移密切相关。我们总结了PHLDA1的结构和生物学特性的最新研究进展，以及PHLDA1在乳腺癌、癌、肝癌、胃癌、黑色素瘤和骨肉瘤等多种恶性肿瘤中的作用，旨在全面揭示PHLDA1在肿瘤临床诊断中的意义。
