健康早产儿前囟门早闭的神经发育特征。
The neurodevelopmental profile of healthy children with premature anterior fontanel closure.
机构信息
Department of Pediatric Neurology, Faculty of Medicine, Mersin University, Mersin, Turkey.
Department of Medical Education, Faculty of Medicine, Mersin University, Mersin, Turkey.
出版信息
Turk J Med Sci. 2022 Aug;52(4):934-941. doi: 10.55730/1300-0144.5393. Epub 2022 Aug 10.
BACKGROUND
We aimed to assess the neurodevelopmental status of healthy children with premature anterior fontanel closure.
METHODS
This retrospective observational study was conducted on 40 (20 M, 20 F) children admitted to Mersin University Pediatric Neurology Outpatient Clinic between 2015-2020 with complaints of premature fontanel closure. Patients with dysmorphic features, microcephaly, craniosynostosis, hypoxic-ischemic sequelae, infections, metabolic disorders, intracranial hemorrhage, epilepsy, endocrine problems, additional congenital anomalies, intrauterine growth retardation (IUGR), prematurity, and postmaturity were excluded. The Denver II and Bayley III tests were applied to all patients and controls.
RESULTS
The Denver II identified retardations in gross motor skills (p = 0.015) and personal-social skills (p = 0.042) and Bayley III in cognitive (p = 0.030) and motor skills (p = 0.007) in the study group. None of the participants in the study group had neurodevelopmental retardation, according to the Bayley III normal standards.
DISCUSSION
Our results suggest that children with premature fontanel closure may develop motor retardation. These children should, therefore, be closely monitored for neurodevelopmental aspects.
背景
我们旨在评估前囟过早闭合的健康儿童的神经发育状况。
方法
这是一项回顾性观察研究，共纳入 2015 年至 2020 年间因前囟过早闭合就诊于梅斯大学儿科神经病学门诊的 40 名（20 名男性，20 名女性）儿童。排除有发育异常、小头畸形、颅缝早闭、缺氧缺血后遗症、感染、代谢紊乱、颅内出血、癫痫、内分泌问题、其他先天性畸形、宫内生长迟缓（IUGR）、早产和过期产的患者。所有患者和对照组均进行 Denver II 和 Bayley III 测试。
结果
Denver II 发现研究组的粗大运动技能（p=0.015）和个人-社会技能（p=0.042）发育迟缓，Bayley III 发现认知（p=0.030）和运动技能（p=0.007）发育迟缓。根据 Bayley III 的正常标准，研究组中没有儿童存在神经发育迟缓。
讨论
我们的结果表明，前囟过早闭合的儿童可能存在运动发育迟缓。因此，这些儿童应密切监测神经发育方面。
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