Ritter J K, Franklin M R
Biochem Pharmacol. 1987 Sep 1;36(17):2783-7. doi: 10.1016/0006-2952(87)90265-6.
A 4-fold induction of hepatic microsomal cytochrome P-450 following 3 days of treatment of rats with clotrimazole (75 mg/kg), a potent monooxygenase inhibitor, greatly exceeded that evident from similar phenobarbital and dexamethasone treatment. The clotrimazole-induced microsomes exhibited a pattern of monooxygenase activities similar to that seen in microsomes from both phenobarbital- and dexamethasone-treated animals. Precautions were necessary to determine both monooxygenase activities and the full amount of cytochrome P-450 present in microsomes because of interference by residual clotrimazole in the microsomes.
用强效单加氧酶抑制剂克霉唑（75毫克/千克）对大鼠进行3天治疗后，肝微粒体细胞色素P - 450诱导了4倍，这大大超过了用类似的苯巴比妥和地塞米松治疗所观察到的诱导程度。克霉唑诱导的微粒体表现出的单加氧酶活性模式，与苯巴比妥和地塞米松治疗动物的微粒体中所观察到的相似。由于微粒体中残留的克霉唑会产生干扰，因此在测定微粒体中的单加氧酶活性和细胞色素P - 450的总量时都需要采取预防措施。
