Kojima S, Ito K
Nephron. 1986;42(1):78-82. doi: 10.1159/000183638.
Fifty-five male Wistar rats were divided into four groups and were fed (1) a control diet, (2) a high-salt low-protein (HSLP) diet, (3) a high-salt standard protein (HSSP) diet, or (4) a high-salt high-protein (HSHP) diet for 17 weeks in order to assess the effects of these diets on blood pressure, sodium metabolism, and urinary kallikrein excretion. Mean blood pressure on the 17th week was 156 +/- (SE)3 mm Hg in the HSLP group, and 152 +/- 3 mm Hg in the HSSP group. These values were significantly higher than 126 +/- 4 mm Hg in the HSHP group. Blood pressure showed reciprocal relationships to both urinary sodium and kallikrein excretion. These results suggest that high protein intake suppresses the rise of blood pressure of salt-loaded rats by facilitating sodium excretion and activating the renal kallikrein-kinin system.
55只雄性Wistar大鼠被分为四组，分别喂食：(1) 对照饮食；(2) 高盐低蛋白（HSLP）饮食；(3) 高盐标准蛋白（HSSP）饮食；或(4) 高盐高蛋白（HSHP）饮食，持续17周，以评估这些饮食对血压、钠代谢和尿激肽释放酶排泄的影响。第17周时，HSLP组的平均血压为156±（标准误）3 mmHg，HSSP组为152±3 mmHg。这些值显著高于HSHP组的126±4 mmHg。血压与尿钠排泄和激肽释放酶排泄均呈反比关系。这些结果表明，高蛋白摄入通过促进钠排泄和激活肾激肽释放酶-激肽系统，抑制了盐负荷大鼠血压的升高。
