使用体腔镜活检标本离体内吞镜检查对 3 例间皮瘤患者进行超放大成像。

Ultra-magnifying Imaging of Thoracoscopic Biopsy Specimens Using Ex vivo Endocytoscopy in Three Patients with Mesothelioma.

机构信息

Department of Internal Medicine, Division of Medical Oncology & Respiratory Medicine, Faculty of Medicine, Shimane University, Japan.

出版信息

Intern Med. 2022;61(21):3251-3257. doi: 10.2169/internalmedicine.9173-21. Epub 2022 Nov 1.

DOI:10.2169/internalmedicine.9173-21

PMID:36328587

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9683823/

Abstract

We performed endocytoscopy (ECS) for the ex vivo evaluation of mesothelioma in specimens biopsied during medical thoracoscopy in three patients. We evaluated 19 biopsy specimens based on the density of nuclei and irregularity in the nuclei shape using ECS and compared them with the histopathological findings. All 10 specimens considered malignant based on ECS were diagnosed as malignant based on histopathology. The nine specimens evaluated as non-malignant based on ECS consisted of six specimens diagnosed as malignant based on histopathology and three diagnosed as non-malignant based on histopathology. ECS was feasible and had some utility for ex vivo ultra-magnifying imaging of thoracoscopic biopsy specimens from patients with mesothelioma.

摘要

我们对在三名患者的胸腔镜检查中活检的间皮瘤标本进行了内视镜检查（ECS），以进行体外评估。我们使用 ECS 根据细胞核密度和细胞核形状的不规则性评估了 19 个活检标本，并将其与组织病理学发现进行了比较。所有 10 个根据 ECS 认为是恶性的标本根据组织病理学均被诊断为恶性。根据 ECS 评估为非恶性的 9 个标本中，有 6 个标本根据组织病理学诊断为恶性，3 个标本根据组织病理学诊断为非恶性。ECS 对于来自间皮瘤患者的胸腔镜检查活检标本的体外超放大成像具有一定的可行性和一定的实用性。