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Coffee reduces the risk of hepatocellular carcinoma probably through inhibition of NLRP3 inflammasome activation by caffeine.

作者信息

Fan Frank S

机构信息

Section of Hematology and Oncology, Department of Medicine, Ministry of Health and Welfare Taitung Hospital, Taitung County, Taiwan.

出版信息

Front Oncol. 2022 Oct 18;12:1029491. doi: 10.3389/fonc.2022.1029491. eCollection 2022.

DOI:10.3389/fonc.2022.1029491
PMID:36330474
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9623052/
Abstract
摘要

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RNA adenosine deaminase (ADAR1) alleviates high-fat diet-induced nonalcoholic fatty liver disease by inhibiting NLRP3 inflammasome.RNA 腺苷脱氨酶（ADAR1）通过抑制 NLRP3 炎性体缓解高脂肪饮食诱导的非酒精性脂肪性肝病。
Lab Invest. 2022 Oct;102(10):1088-1100. doi: 10.1038/s41374-022-00805-8. Epub 2022 Jun 11.
2
Melatonin Suppresses NLRP3 Inflammasome Activation via TLR4/NF-κB and P2X7R Signaling in High-Fat Diet-Induced Murine NASH Model.褪黑素通过TLR4/NF-κB和P2X7R信号通路抑制高脂饮食诱导的小鼠非酒精性脂肪性肝炎模型中NLRP3炎性小体的激活。
J Inflamm Res. 2022 May 31;15:3235-3258. doi: 10.2147/JIR.S343236. eCollection 2022.
3
Protective Effects of Tiaoganquzhi Decoction in Treating inflammatory Injury of Nonalcoholic Fatty liver Disease by Promoting CGI-58 and Inhibiting Expression of NLRP3 Inflammasome.调肝祛脂汤通过促进CGI-58和抑制NLRP3炎性小体表达对非酒精性脂肪性肝病炎症损伤的保护作用
Front Pharmacol. 2022 May 2;13:851267. doi: 10.3389/fphar.2022.851267. eCollection 2022.
4
Mitochondria and the NLRP3 Inflammasome in Alcoholic and Nonalcoholic Steatohepatitis.线粒体与 NLRP3 炎性体在酒精性和非酒精性脂肪性肝炎中的作用
Cells. 2022 Apr 27;11(9):1475. doi: 10.3390/cells11091475.
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Caffeine Citrate Protects Against Sepsis-Associated Encephalopathy and Inhibits the UCP2/NLRP3 Axis in Astrocytes.柠檬酸咖啡因可预防脓毒症相关性脑病并抑制星形胶质细胞中的UCP2/NLRP3轴。
J Interferon Cytokine Res. 2022 Jun;42(6):267-278. doi: 10.1089/jir.2021.0241. Epub 2022 Apr 13.
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Multi-faceted role of pyroptosis mediated by inflammasome in liver fibrosis.炎性小体介导热激细胞死亡在肝纤维化中的多效性作用。
J Cell Mol Med. 2022 May;26(10):2757-2765. doi: 10.1111/jcmm.17277. Epub 2022 Apr 12.
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The NLRP3 Inflammasome in Non-Alcoholic Fatty Liver Disease and Steatohepatitis: Therapeutic Targets and Treatment.非酒精性脂肪性肝病和脂肪性肝炎中的NLRP3炎性小体：治疗靶点与治疗方法
Front Pharmacol. 2022 Mar 8;13:780496. doi: 10.3389/fphar.2022.780496. eCollection 2022.
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Cell-to-Cell Communications in Alcohol-Associated Liver Disease.酒精性肝病中的细胞间通讯
Front Physiol. 2022 Feb 21;13:831004. doi: 10.3389/fphys.2022.831004. eCollection 2022.
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Caffeine treatment started before injury reduces hypoxic-ischemic white-matter damage in neonatal rats by regulating phenotypic microglia polarization.咖啡因治疗在损伤前开始可通过调节表型小胶质细胞极化减轻新生大鼠缺氧缺血性白质损伤。
Pediatr Res. 2022 Dec;92(6):1543-1554. doi: 10.1038/s41390-021-01924-6. Epub 2022 Feb 26.