Sichuan Provincial Center for Mental Health, The Center of Psychosomatic Medicine of Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Mental Health Center and Psychiatric Laboratory, West China Hospital of Sichuan University, Chengdu 610041, China; Huaxi Brain Research Center, West China Hospital of Sichuan University, Chengdu 610041, Sichuan, China; Med-X Center for Informatics, Sichuan University, Chengdu 610041, Sichuan, China.
Neurosci Biobehav Rev. 2022 Dec;143:104929. doi: 10.1016/j.neubiorev.2022.104929. Epub 2022 Oct 27.
Major depressive disorder (MDD) patients demonstrate abnormal neural activation even after complete remission. Many task-related functional magnetic resonance imaging (fMRI) studies have focused on changes in brain function in individuals with remitted MDD (rMDD). We conducted a meta-analysis of these studies to explore differences in brain activation between patients with rMDD and healthy controls (HCs). Our meta-analysis included 13 studies, encompassing 18 experiments, 304 rMDD patients and 321 HCs. Patients with rMDD showed increased neural activation in the left inferior parietal gyrus and right fusiform gyrus and decreased neural activation in the left superior frontal gyrus, right middle temporal gyrus and right Heschl gyrus. Meta-regression analysis revealed that patient age and the number of depressive episodes were negatively associated with brain activity in the left superior frontal gyrus. Our findings suggest abnormal brain function, especially in areas involved in cognitive function, emotion regulation and perception, in rMDD patients; alterations of these regions may be the primary or secondary neurophysiological mechanisms underlying MDD and provide potential neuroimaging targets for early screening.
重度抑郁症（MDD）患者即使在完全缓解后也表现出异常的神经激活。许多与任务相关的功能磁共振成像（fMRI）研究都集中在缓解期 MDD（rMDD）个体的大脑功能变化上。我们对这些研究进行了荟萃分析，以探讨 rMDD 患者与健康对照组（HCs）之间大脑激活的差异。我们的荟萃分析包括 13 项研究，涵盖 18 个实验，304 名 rMDD 患者和 321 名 HCs。rMDD 患者表现出左侧顶下小叶和右侧梭状回的神经激活增加，左侧额上回、右侧颞中回和右侧 Heschl 回的神经激活减少。元回归分析表明，患者年龄和抑郁发作次数与左侧额上回的脑活动呈负相关。我们的研究结果表明，rMDD 患者存在异常的大脑功能，特别是在涉及认知功能、情绪调节和感知的区域；这些区域的改变可能是 MDD 的主要或次要神经生理机制，并为早期筛查提供潜在的神经影像学靶点。
