勇敢的记忆 T 细胞在与病原体的对抗中坚守阵地。
Gutsy memory T cells stand their ground against pathogens.
机构信息
Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Department of Surgery, Columbia University Irving Medical Center, New York, NY 10032, USA.
出版信息
Sci Immunol. 2022 Nov 11;7(77):eade7168. doi: 10.1126/sciimmunol.ade7168. Epub 2022 Nov 4.
PMID:36332008
Abstract
Elegant fate-mapping models to label intestinal tissue-resident memory CD8 T (T) cells demonstrate retention and lack of expansion of CD103 T cells, whereas intestinal CD103 memory cells expand, forming both new tissue-localized CD103 and CD103 T cells (see related Research Articles by Fung and von Hoesslin ).
摘要
优雅的命运映射模型可用于标记肠道组织驻留记忆 CD8 T（T）细胞，该模型显示 CD103 T 细胞的保留和缺乏扩增，而肠道 CD103 记忆细胞则扩增，形成新的组织定位的 CD103 和 CD103 T 细胞（参见 Fung 和 von Hoesslin 的相关研究文章）。
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