Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA; Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA; Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
Immunity. 2024 Aug 13;57(8):1734-1751. doi: 10.1016/j.immuni.2024.06.017.
Tissue-resident memory T (T) cells positively correlate with cancer survival, but the anti-tumor mechanisms underlying this relationship are not understood. This review reconciles these observations, summarizing concepts of T cell immunosurveillance, fundamental T cell biology, and clinical observations on the role of T cells in cancer and immunotherapy outcomes. We also discuss emerging strategies that utilize T-phenotype cells for patient diagnostics, staging, and therapy. Current challenges are highlighted, including a lack of standardized T cell nomenclature and our limited understanding of relationships between T cell markers and underlying tumor biology. Existing findings are integrated into a summary of the field while emphasizing opportunities for future research.
组织驻留记忆 T（T）细胞与癌症存活呈正相关，但尚不清楚这种关系背后的抗肿瘤机制。本综述调和了这些观察结果，总结了 T 细胞免疫监视、T 细胞基本生物学以及 T 细胞在癌症和免疫治疗结果中的作用的临床观察。我们还讨论了利用 T 表型细胞进行患者诊断、分期和治疗的新兴策略。突出了当前的挑战，包括缺乏标准化的 T 细胞命名法以及我们对 T 细胞标志物与潜在肿瘤生物学之间关系的理解有限。将现有研究结果整合到该领域的总结中，同时强调未来研究的机会。
