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儿童超重和肥胖以及出生时异常的人体测量指标与学龄前儿童哮喘的高发率有关。

Childhood overweight and obesity and abnormal birth anthropometric measures are associated with a higher prevalence of childhood asthma in preschool age.

机构信息

Department of Food Science and Nutrition, School of Environment, University of the Aegean, Myrina, Lemnos, Greece.

Department of Radiotherapy, School of Medicine, University of Crete, Heraklio, Crete, Greece.

出版信息

J Asthma. 2023 Jul;60(7):1316-1325. doi: 10.1080/02770903.2022.2144354. Epub 2022 Dec 1.

DOI:10.1080/02770903.2022.2144354
PMID:36332163
Abstract

OBJECTIVES

Childhood asthma is one of the most common non-communicable diseases in the world. Several perinatal and postnatal factors have been associated with increased risk of developing childhood asthma. The present study aims to assess whether childhood overweight and obesity and abnormal birth anthropometric measures affect the risk of developing childhood asthma in preschool age.

METHODS

In this study, 5215 preschool children at the age of 2-5 years were enrolled after applying several inclusion and exclusion criteria and they examined whether they present asthma symptoms. Non-adjusted and adjusted statistical analysis was performed to assess whether perinatal and postnatal factors increase the risk of developing childhood asthma.

RESULTS

A prevalence of 4.5% of childhood asthma was recorded. Among children diagnosed with asthma, 19.4% were affected by overweight and 13.9% were obese. Childhood overweight/obesity was indepedently associated with a 76% higher risk of childhood asthma than normal weight. Abnormal birth anthropometric measures, i.e. birth weight, length, and head circumference, were independently associated with higher odds (87%, 29%, and 23%, respectively) of childhood asthma than normal ranges.

CONCLUSIONS

This is a cross-sectional, nationally representative study which supported evidence that childhood overweight/obesity and abnormal birth anthropometric measures may independently increase the risk of childhood asthma in preschool age. Emergent health policies and strategies are recommended to promote a healthy lifestyle, preventing childhood obesity at the early stages of life.

摘要

目的

儿童哮喘是世界上最常见的非传染性疾病之一。许多围产期和产后因素与儿童哮喘发病风险增加有关。本研究旨在评估儿童超重和肥胖以及出生时异常的人体测量指标是否会影响学龄前儿童哮喘的发病风险。

方法

本研究纳入了 5215 名 2-5 岁的学龄前儿童,在应用了一些纳入和排除标准后,检查他们是否存在哮喘症状。进行了非调整和调整后的统计分析,以评估围产期和产后因素是否会增加儿童哮喘的发病风险。

结果

记录到儿童哮喘的患病率为 4.5%。在被诊断为哮喘的儿童中,19.4%超重,13.9%肥胖。与正常体重儿童相比,儿童超重/肥胖与哮喘风险增加 76%独立相关。出生时的异常人体测量指标,即体重、身长和头围,与较高的哮喘发病风险独立相关(分别为 87%、29%和 23%)。

结论

这是一项横断面、全国代表性研究,支持了儿童超重/肥胖和出生时异常人体测量指标可能独立增加学龄前儿童哮喘发病风险的证据。建议制定新的卫生政策和策略,以促进健康的生活方式,在生命早期预防儿童肥胖。

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