Department of Biochemistry & Molecular Biology, Tulane University School of Medicine, New Orleans, LA, USA.
Department of Biochemistry & Molecular Biology, Tulane University School of Medicine, New Orleans, LA, USA.
Structure. 2022 Nov 3;30(11):1463-1464. doi: 10.1016/j.str.2022.10.005.
In this issue of Structure, Gihaz and colleagues develop antifungal compounds targeting fungal pantothenate kinase (PanK). Through utilization of high-throughput chemical screening, along with biochemical and functional analyses and newly solved fungal PanK crystal structures, high-affinity inhibitors are produced, and invaluable insights into the mechanisms of fungal PanK are gained.
本期《结构》中，Gihaz 及其同事开发了针对真菌泛酸激酶（PanK）的抗真菌化合物。通过利用高通量化学筛选，以及生化和功能分析以及新解决的真菌 PanK 晶体结构，产生了高亲和力的抑制剂，并深入了解了真菌 PanK 的作用机制。
