吸入物和其他黏膜相关的环境风险因素与类风湿关节炎。
Inhalant and Additional Mucosal-Related Environmental Risks for Rheumatoid Arthritis.
机构信息
Division of Rheumatology & Immunology, University of Nebraska Medical Center, 986270 Nebraska Medical Center, Omaha, NE 68198-6270, USA; VA Nebraska-Western Iowa Health Care System, 4101 Woolworth Avenue, Omaha, NE 68105, USA.
Division of Allergy & Immunology, University of Nebraska Medical Center, 985990 Nebraska Medical Center, Omaha, NE 68198-5990, USA.
出版信息
Rheum Dis Clin North Am. 2022 Nov;48(4):781-798. doi: 10.1016/j.rdc.2022.06.002.
Rheumatoid arthritis (RA) occurs as the result of a complex interplay of environmental factors in a genetically susceptible individual. There is considerable evidence that the lungs may serve as an initial site of tolerance loss in the generation of RA-related autoimmunity, and several environmental inhalant exposures and lung diseases have been associated with RA risk. There is additional evidence that immune and microbial dysregulation of other mucosal sites, including the oral and gastrointestinal mucosa, may contribute to the development of RA. Epidemiologic evidence linking mucosal exposures to various environmental insults as risk determinants in RA will be reviewed.
类风湿关节炎（RA）是在遗传易感性个体中环境因素复杂相互作用的结果。有相当多的证据表明，肺部可能是 RA 相关自身免疫产生中耐受丧失的初始部位，并且几种环境吸入暴露和肺部疾病与 RA 风险相关。还有其他证据表明，包括口腔和胃肠道黏膜在内的其他黏膜部位的免疫和微生物失调可能导致 RA 的发生。本文将综述将黏膜暴露于各种环境刺激物与 RA 的风险决定因素联系起来的流行病学证据。
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