Department of Dermatology, Copenhagen University Hospital, Copenhagen, Denmark.
Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark.
Exp Dermatol. 2023 Apr;32(4):341-347. doi: 10.1111/exd.14703. Epub 2022 Nov 18.
Hydrochlorothiazide (HCTZ) is a frequently prescribed diuretic that exhibits photosensitizing properties. It is used to treat hypertension and edema. Dermato-epidemiological studies in various populations have linked HCTZ treatment with increased risk of particular types of skin cancer, including malignant melanoma (lentigo subtype), and both basal cell carcinoma and squamous cell carcinoma (SCC). This study investigated whether either of two different doses of HCTZ increased the risk of SCC development in mice exposed to ultraviolet radiation (UVR). A total of three groups of hairless mice were used in this study (total, N = 71). One group received a low dose (0.26 mg/mouse/day) and another group received a high dose (0.52 mg/mouse/day) of HCTZ in their drinking water; a third UVR control group received only tap water. All three groups were irradiated with UVR until the mice developed three tumours that were 4 mm in size. The times to SCC tumour development were recorded. In the low-dose group, the median time to develop an SCC tumour was 170 days; in both the high-dose group and the control group, the median time to develop anexd SCC tumour was 163 days (p ≥ 0.331). In our hairless mouse model, we found that mice treated with UVR plus HCTZ did not develop SCCs more rapidly than mice treated with UVR but not HCTZ.
氢氯噻嗪（HCTZ）是一种常用的利尿剂，具有光敏性。它用于治疗高血压和水肿。在不同人群中的皮肤流行病学研究表明，HCTZ 治疗与某些类型皮肤癌的风险增加有关，包括恶性黑色素瘤（痣样亚型）以及基底细胞癌和鳞状细胞癌（SCC）。本研究旨在探讨两种不同剂量的 HCTZ 是否会增加接受紫外线辐射（UVR）照射的小鼠发生 SCC 的风险。本研究共使用了三组无毛小鼠（总数，N=71）。一组在饮用水中接受低剂量（0.26mg/小鼠/天），另一组接受高剂量（0.52mg/小鼠/天）的 HCTZ；第三组 UVR 对照组仅接受自来水。三组均接受 UVR 照射，直至小鼠发展出三个 4mm 大小的肿瘤。记录 SCC 肿瘤发展的时间。在低剂量组中，发展 SCC 肿瘤的中位时间为 170 天；在高剂量组和对照组中，发展 SCC 肿瘤的中位时间均为 163 天（p≥0.331）。在我们的无毛小鼠模型中，我们发现接受 UVR 加 HCTZ 治疗的小鼠与仅接受 UVR 治疗的小鼠相比，并未更快地发展 SCC。
