Gangwani Manesh Kumar, Aziz Muhammad, Nawras Ali, Priyanka Fnu, Ahmed Zohaib, Khan Raja Samir, Qamar Mohammad Aadil, Haroon Fawad, Aziz Abeer, Smith Wade Lee, Kirshan Ravi Shri Jai, Parikh Vishal, Alyousif Zakaria, Mahmood Asif, Tariq Raseen, Rai Devesh, Aronow Wilbert S
Department of Medicine, University of Toledo Medical Center, Toledo, OH 43614, USA.
Department of Gastroenetrology, University of Toledo Medical Center, Toledo, OH 43614, USA.
Future Cardiol. 2022 Dec;18(12):957-967. doi: 10.2217/fca-2022-0054. Epub 2022 Nov 5.
Our study aims to provide a more holistic understanding of the available data and predictive risk factors for gastrointestinal bleed (GIB). We searched MEDLINE, Embase, Cochrane Central Register of Controlled Trials and Web of Science Core Collection and calculated relative risk and meta-regression was utilized to evaluate for risk factors in order to assess the effect of covariates. Our meta-analysis reported a pooled prevalence rate of GIB of 24.4%. Meta-regression analysis did not yield a statistically significant association between GIB and risk factors, including age, gender, hypertension, chronic kidney disease and diabetes. Studies investigating larger sample sizes are required for conclusive findings.
我们的研究旨在更全面地了解胃肠道出血（GIB）的现有数据和预测风险因素。我们检索了MEDLINE、Embase、Cochrane对照试验中央注册库和科学网核心合集，并计算了相对风险，利用meta回归分析评估风险因素，以评估协变量的影响。我们的meta分析报告GIB的合并患病率为24.4%。meta回归分析未发现GIB与包括年龄、性别、高血压、慢性肾病和糖尿病在内的风险因素之间存在统计学上的显著关联。需要开展更大样本量的研究才能得出确凿结论。
