非离子型疏水性 DES-DLLME 与进样口硅烷化-GC-MS/MS 联用的实验设计，用于定量测定食品样品中的 13 种双酚。
Experimental design of non-ionic hydrophobic DES-DLLME coupled with injector port silylation-GC-MS/MS for the quantitative determination of 13 bisphenols in food samples.
机构信息
Analytical and Structural Chemistry Department, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad, 500007, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.
Analytical and Structural Chemistry Department, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad, 500007, India.
出版信息
Food Chem. 2023 Mar 30;405(Pt A):134778. doi: 10.1016/j.foodchem.2022.134778. Epub 2022 Oct 28.
Non-ionic hydrophobic deep eutectic solvent based DLLME method with thymol and camphor (1:1 mole ratio) as extraction solvent and acetonitrile as disperser solvent was developed for the determination of 13 bisphenols (BPs) in food commodities by auto IPS-GC-MS/MS. Further, the influential parameters pH, vortex time, and volume of NIHDES for extraction of 13 BPs were optimized by employing the design of experiment. The LOQ and recoveries were observed to be 0.1 ng mL, and 77.8-109.2%, respectively. The expanded uncertainty was found to be 4.8-18.0% for the developed and validated method, which was applied to food commodities to determine 13 BPs and their levels were in the range of 0.01-1.24 ng mL in liquid foods (milk, water, and beverages) and 0.29-3.25 ng g in meat samples (goat, chicken, and fish). The present green analytical method is highly suitable for the rapid determination of 13 BPs in food commodities for routine analysis.
非离子型疏水深共晶溶剂（以百里酚和樟脑（1:1 摩尔比）为萃取溶剂，乙腈为分散溶剂）结合自动内标-气相色谱-串联质谱法（IPS-GC-MS/MS）用于测定食品中 13 种双酚（BP）。进一步通过实验设计优化了提取 13 种 BP 的深共晶溶剂的 pH 值、涡旋时间和体积等影响参数。该方法的检出限和回收率分别为 0.1ng/mL 和 77.8-109.2%。所建立和验证的方法的扩展不确定度为 4.8-18.0%，该方法已应用于食品中 13 种 BP 的测定，其含量范围为液体食品（牛奶、水和饮料）中的 0.01-1.24ng/mL 和肉样（山羊、鸡和鱼）中的 0.29-3.25ng/g。该绿色分析方法非常适用于食品中 13 种 BP 的常规分析快速测定。
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