Department of Animal Science and Technology, Chung-Ang University, Anseong, Gyeonggi-do 17546, Republic of Korea; Department of Biotechnology, Korea University, Seoul 02841, Republic of Korea.
Division of Pediatric General and Thoracic Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Meat Sci. 2023 Jan;195:109015. doi: 10.1016/j.meatsci.2022.109015. Epub 2022 Oct 21.
Pork belly, which contains various components of muscle and fat, is one of the most favorable parts of pork. However, pig-breeding has largely focused on improving longissimus thoracis, representing the lean-meat production capacity, and the quality of pork belly has not improved because of the absence of established standards. Previous studies have suggested a standard for the establishment of such standards and relevant genetic parameters, but no key gene has been identified yet. Here, we predicted key genes, including transcription factors, related to pork belly formation. We analyzed 543 Yorkshire pigs and their SNP chip data and identified 3238 genes and 135,025 edges related to pork belly traits by using the association weight matrix. Based on these results, in silico validation was performed. The predicted nine transcription factors, including the key trio, were enriched in adipogenesis-related signaling pathways. The transcription factors and corresponding genetic network identified in this study may be useful in improving pork belly parameters.
五花肉含有各种肌肉和脂肪成分，是猪肉中最受欢迎的部分之一。然而，由于缺乏既定的标准，猪的养殖主要集中在提高胸腰椎的瘦肉生产能力上，而五花肉的质量并没有得到改善。先前的研究已经提出了建立这些标准和相关遗传参数的标准，但尚未确定关键基因。在这里，我们预测了与五花肉形成相关的关键基因，包括转录因子。我们分析了 543 头约克夏猪及其 SNP 芯片数据，并通过关联权重矩阵鉴定了与五花肉性状相关的 3238 个基因和 135025 个基因。基于这些结果，我们进行了计算机验证。预测的九个转录因子，包括关键的 trio，在脂肪生成相关信号通路中富集。本研究中鉴定的转录因子和相应的遗传网络可能有助于改善五花肉参数。
