Department of Ophthalmology, Chang Gung Memorial Hospital, 5 Fu-Hsin Street, Kweishan, Taoyuan, 33305, Taiwan.
College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Sci Rep. 2022 Nov 5;12(1):18788. doi: 10.1038/s41598-022-22338-2.
The effect of anti-vascular endothelial growth factor on neonatal lung development was inconclusive. To evaluate pulmonary function in school-age children who have received intravitreal bevacizumab (IVB) for retinopathy of prematurity (ROP), this study included 118 school-aged children who were grouped into three groups: full-term control children (group 1), preterm children who had not received IVB treatment (group 2) and preterm children with ROP who had received IVB treatment (group 3). Pulmonary function was measured by spirometry and impulse oscillometry. Pulmonary function was significantly better in group 1 than in groups 2 and 3 (all p < 0.05 in forced vital capacity (FVC), forced expiratory volume in 1 s (FEV), forced expiratory flow between 25 and 75% of FVC (FEF), and respiratory resistance at 5 Hz and difference between respiratory resistance at 5 and 20 Hz (R5-R20). There were no statistically significant differences between group 2 and group 3 in all pulmonary function parameters, including FVC, FEV, ratio of FEV to FVC, FEF, R5, R20, R5-R20, and respiratory reactance at 5 Hz. In conclusion, our study revealed that preterm infants receiving IVB for ROP had comparable pulmonary function at school age to their preterm peers who had not received IVB treatment.
抗血管内皮生长因子对新生儿肺发育的影响尚无定论。为了评估接受玻璃体内注射贝伐单抗（IVB）治疗早产儿视网膜病变（ROP）的学龄儿童的肺功能，本研究纳入了 118 名学龄儿童，分为三组：足月对照组儿童（第 1 组）、未接受 IVB 治疗的早产儿（第 2 组）和接受 IVB 治疗的 ROP 早产儿（第 3 组）。通过肺活量计和脉冲振荡法测量肺功能。第 1 组的肺功能明显优于第 2 组和第 3 组（所有用力肺活量（FVC）、第 1 秒用力呼气量（FEV）、FVC 之间 25%至 75%的用力呼气流量（FEF）、5Hz 呼吸阻力和 5Hz 与 20Hz 呼吸阻力之间的差异（R5-R20）差异均有统计学意义（p均<0.05）。在所有肺功能参数中，第 2 组和第 3 组之间均无统计学差异，包括 FVC、FEV、FEV/FVC 比值、FEF、R5、R20、R5-R20 和 5Hz 呼吸反应性。总之，本研究表明，接受 IVB 治疗 ROP 的早产儿在学龄期的肺功能与未接受 IVB 治疗的早产儿相当。
