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常见儿科神经系统疾病谱:一项来自巴基斯坦三个三级医疗中心的横断面研究。

Spectrum of Common Pediatric Neurological Disorders: A Cross-Sectional Study From Three Tertiary Care Centres Across Pakistan.

作者信息

Chand Prem, Sultan Tipu, Kulsoom Shazia, Jan Farida, Ibrahim Shahnaz, Mukhtiar Khairunnisa, Awan Safia, Rafique Ibrar, Khan Durray Shahwar A, Sulaiman Asna, Saqib Muhammad Arif Nadeem, Sajid Muhammad, Padhani Zahra Ali, Das Jai K, Soomro Shazia, Wasay Mohammad

机构信息

Department of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan.

Children Hospital, University of Child Health Sciences, Lahore, Pakistan.

出版信息

Pediatr Neurol. 2023 Jan;138:33-37. doi: 10.1016/j.pediatrneurol.2022.09.005. Epub 2022 Oct 7.

Abstract

BACKGROUND

There is dearth of information on the spectrum of neurological disorders among children less than 18 years of age. The aim of this study is to identify the commonly presenting neurological disorders among children aged ≤ 18 years in Pakistan.

METHODS

We conducted a cross-sectional study at three tertiary care hospitals in Pakistan.

RESULTS

A total of 17,176 children were included in our study; 61.8% were boys and 38.2% females. The most commonly presenting neurological disorder was epilepsy (36%), followed by behavior disorders (16%) and cerebral palsy (10.5%). There was significant difference between children less than 5 years and greater than 5 years age groups, with less than 5 years age group showing higher prevalence for behavioral disorders (P < 0.001), cerebral palsy (P < 0.001), infections (P = 0.014), sequalae (P < 0.001), and developmental disorders (P < 0.001). Gender-wise distribution showed epilepsy to be the most common neurological disorder among both genders, with a significant difference being reported between gender and epilepsy (P = 0.009), headache disorders (P < 0.001), neuroinflammatory disorders (P = 0.025), neurocutaneous syndromes (P < 0.001), behavioral diseases (P < 0.001), cerebral palsy (P = 0.009), and movement disorders (P < 0.001).

CONCLUSIONS

The result of this analysis helps to assess the commonly presenting neurological disorders in children. This study will help health care workers in resource-poor settings within Pakistan to be mindful of the common neurological disorders while diagnosing a child with neurological symptoms in an outpatient setting. Health care providers need to be trained to identify and treat these common conditions; however, there is still a dire need for more trained neurologists across the country.

摘要

背景

关于18岁以下儿童神经疾病谱的信息匮乏。本研究的目的是确定巴基斯坦18岁及以下儿童中常见的神经疾病。

方法

我们在巴基斯坦的三家三级医疗机构进行了一项横断面研究。

结果

我们的研究共纳入17176名儿童;其中61.8%为男孩,38.2%为女孩。最常见的神经疾病是癫痫(36%),其次是行为障碍(16%)和脑瘫(10.5%)。5岁以下儿童和5岁以上儿童年龄组之间存在显著差异,5岁以下年龄组在行为障碍(P<0.001)、脑瘫(P<0.001)、感染(P=0.014)、后遗症(P<0.001)和发育障碍(P<0.001)方面的患病率较高。按性别分布显示,癫痫是两性中最常见的神经疾病,性别与癫痫(P=0.009)、头痛障碍(P<0.001)、神经炎性疾病(P=0.025)、神经皮肤综合征(P<0.001)、行为疾病(P<0.001)、脑瘫(P=0.009)和运动障碍(P<0.001)之间存在显著差异。

结论

该分析结果有助于评估儿童中常见的神经疾病。本研究将帮助巴基斯坦资源匮乏地区的医护人员在门诊诊断有神经症状的儿童时,留意常见的神经疾病。医护人员需要接受培训以识别和治疗这些常见病症;然而,该国仍然迫切需要更多训练有素的神经科医生。

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