Servei de Diagnòstic de Patologia Veterinària, Barcelona, Spain.
Department de Medicina i Cirurgia Animals, Barcelona, Spain.
J Comp Pathol. 2022 Nov;199:81-85. doi: 10.1016/j.jcpa.2022.09.006. Epub 2022 Nov 4.
A 10-year-old peach-faced lovebird (Agapornis roseicollis) was evaluated for an ulcerated and painful mass at the location of a fracture 2 years previously. Whole body radiographs showed a humeral fracture with a presumptive neoplastic proliferation in the distal diaphysis. Right wing amputation was elected but the animal died during recovery from surgery. Histopathological examination of the amputated wing revealed an infiltrative sarcomatous neoplastic proliferation. Immunohistochemistry (IHC) was carried out to characterize the tumour using antibodies against vimentin, desmin, smooth muscle actin (SMA), S-100, ionized calcium-binding adapter molecule-1 (IBA-1), CD18, cytokeratin and epithelial membrane antigen (EMA). The mesenchymal component of the mass was immunolabelled for vimentin and SMA and sparse epithelial cells were immunopositive for cytokeratin. Very few scattered cells were immunopositive for CD18 and IBA-1. The final diagnosis was consistent with an undifferentiated sarcoma with intralesional hyperplastic epithelium. According to the location, the history of a previous fracture and the histological pattern and IHC profile, the tumour was classified as an undifferentiated sarcoma with entrapped air sac epithelium.
一只 10 岁的桃面爱情鸟（Agapornis roseicollis）因 2 年前骨折部位的溃疡性疼痛肿块而接受评估。全身 X 光片显示肱骨骨折，远端干骺端有疑似肿瘤性增生。选择了右翅截肢，但动物在手术后恢复过程中死亡。对截肢翅膀的组织病理学检查显示出一种浸润性肉瘤性肿瘤增生。使用针对波形蛋白、结蛋白、平滑肌肌动蛋白 (SMA)、S-100、钙结合衔接蛋白-1 (IBA-1)、CD18、细胞角蛋白和上皮膜抗原 (EMA) 的抗体进行免疫组织化学 (IHC) 以表征肿瘤。肿块的间质成分对波形蛋白和 SMA 免疫标记，稀疏的上皮细胞对细胞角蛋白免疫阳性。极少数散在细胞对 CD18 和 IBA-1 免疫阳性。最终诊断为具有腔内增生上皮的未分化肉瘤。根据位置、先前骨折的病史以及组织学模式和 IHC 特征，该肿瘤被归类为伴有包裹气囊上皮的未分化肉瘤。
