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非特指弥漫性大 B 细胞淋巴瘤中细胞角蛋白和 CD56 的异常共表达，经细针穿刺抽吸细胞学检查误诊为转移性神经内分泌癌。

Cytokeratin and CD56 aberrant co-expression in diffuse large B-cell lymphoma, NOS misinterpreted as metastatic neuroendocrine carcinoma by FNAC.

机构信息

Department of Cytopathology, Institute of Oncology Ljubljana, Ljubljana, Slovenia.

Department of Pathology, Institute of Oncology Ljubljana, Ljubljana, Slovenia.

出版信息

Cytopathology. 2023 Mar;34(2):165-168. doi: 10.1111/cyt.13190. Epub 2022 Dec 7.

DOI:10.1111/cyt.13190
PMID:36336889
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10108145/
Abstract

Aberrant expression of epithelial and neuroendocrine markers is rare in diffuse large B-cell lymphoma (DLBCL) and can lead to erroneous diagnosis with inappropriate treatment. This case report describes a case of DLBCL with a co-expression of cytokeratins and CD56 that was misdiagnosed as metastatic neuroendocrine carcinoma.

摘要

上皮和神经内分泌标志物在弥漫性大 B 细胞淋巴瘤 (DLBCL) 中表达异常较为罕见，可能导致误诊并进行不适当的治疗。本病例报告描述了一例伴有细胞角蛋白和 CD56 共表达的 DLBCL，误诊为转移性神经内分泌癌。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2f2/10108145/0839cef98853/CYT-34-165-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2f2/10108145/b7df4b76b076/CYT-34-165-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2f2/10108145/0839cef98853/CYT-34-165-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2f2/10108145/b7df4b76b076/CYT-34-165-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2f2/10108145/0839cef98853/CYT-34-165-g003.jpg

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本文引用的文献

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Aberrant Expression of Immunohistochemical Markers in Malignant Melanoma: A Review.恶性黑色素瘤中免疫组化标志物的异常表达：综述
Dermatopathology (Basel). 2021 Aug 3;8(3):359-370. doi: 10.3390/dermatopathology8030040.
2
Cytokeratin expression in plasmablastic lymphoma - a possible diagnostic pitfall in the routine work-up of tumours.浆母细胞性淋巴瘤中细胞角蛋白的表达 - 常规肿瘤检查中的一个潜在诊断陷阱。
Histopathology. 2021 May;78(6):831-837. doi: 10.1111/his.14300. Epub 2020 Dec 25.
3
Aberrant expression of TTF1, p63, and cytokeratins in a diffuse large B-cell lymphoma.
TTF1、p63 和细胞角蛋白在弥漫性大 B 细胞淋巴瘤中的异常表达。
Diagn Cytopathol. 2021 Feb;49(2):E75-E79. doi: 10.1002/dc.24588. Epub 2020 Sep 1.
4
Immunocytochemistry practices in European cytopathology laboratories-Review of European Federation of Cytology Societies (EFCS) online survey results with best practice recommendations.欧洲细胞病理学实验室的免疫细胞化学实践-审查欧洲细胞学会联合会（EFCS）在线调查结果及最佳实践建议。
Cancer Cytopathol. 2020 Oct;128(10):757-766. doi: 10.1002/cncy.22311. Epub 2020 Jun 29.
5
Clinical and prognostic significance of aberrant T-cell marker expression in 225 cases of de novo diffuse large B-cell lymphoma and 276 cases of other B-cell lymphomas.225例初发弥漫性大B细胞淋巴瘤及276例其他B细胞淋巴瘤中异常T细胞标志物表达的临床及预后意义
Oncotarget. 2017 May 16;8(20):33487-33500. doi: 10.18632/oncotarget.16532.
6
Immunohistochemistry in undifferentiated neoplasm/tumor of uncertain origin.起源不明的未分化肿瘤的免疫组织化学
Arch Pathol Lab Med. 2014 Dec;138(12):1583-610. doi: 10.5858/arpa.2014-0061-RA.
7
Cytokeratin expression in hematological neoplasms: a tissue microarray study on 866 lymphoma and leukemia cases.细胞角蛋白在血液系统肿瘤中的表达：一项对866例淋巴瘤和白血病病例的组织芯片研究
Pathol Res Pract. 2008;204(8):569-73. doi: 10.1016/j.prp.2008.02.008. Epub 2008 Apr 23.
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Nonsmall cell lung carcinoma with neuroendocrine differentiation--an entity of no clinical or prognostic significance.具有神经内分泌分化的非小细胞肺癌——一个无临床或预后意义的实体。
Am J Surg Pathol. 2007 Jan;31(1):26-32. doi: 10.1097/01.pas.0000213319.04919.97.
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