Risk Factors and Clinical Impact of Carbapenem-Resistant Coinfections Among Hospitalized Patients with Infection.

INTRODUCTION

The risk factors and clinical impact of carbapenem-resistant (CRE) coinfection among hospitalized patients with infection (CDI) were analyzed in this study.

MATERIALS AND METHODS

A clinical study was performed at the medical wards of Tainan Hospital, Ministry of Health and Welfare in southern Taiwan. Patients with CDI between January 2013 and April 2020 were included.

RESULTS

Among 238 patients included for analysis, 22 (9.2%) patients developed CRE coinfections within 14 days before or after the onset of CDI. CDI patients with CRE coinfection had longer hospitalization stays (103.0 ± 97.0 days vs 42.5 ± 109.6 days, = 0.01) than those without CRE coinfection. In the multivariate analysis, age (odds ratio [OR] 1.05, 95% confidence interval [CI] 1.01-1.10, = 0.02) was independently associated with CRE coinfection. In contrast, underlying old stroke (OR 0.15, 95% CI 0.03-0.70, = 0.02) was negatively linked to CRE coinfection.

CONCLUSION

Among patients with CDI, CRE coinfections were associated with prolonged hospitalization for CDI. Age was an independent risk factor for CRE coinfection among patients with CDI.