Prim Jessica G, de Oliveira Eduardo B, Veronese Anderson, Chebel Ricardo C, Galvão Klibs N
Department of Large Animal Clinical Sciences, University of Florida, Gainesville 32608.
Department of Animal Sciences, University of Florida, Gainesville 32608.
JDS Commun. 2022 Jun 7;3(4):265-269. doi: 10.3168/jdsc.2022-0221. eCollection 2022 Jul.
The main objective was to characterize behavioral changes in metritic primiparous cows treated with chitosan microparticles (CM) or ceftiofur (CEF). A secondary objective was to compare behavioral patterns of metritic cows with nonmetritic (NMET) cows. Nulliparous Holstein cows (n = 311) were fitted with a neck-mounted automated health-monitoring device (AHMD) from -21 to 60 d relative to calving. Cows diagnosed with metritis (d 0), characterized by watery, fetid, red-brownish uterine discharge within 21 d in milk were assigned randomly to CM (n = 45), intrauterine infusion of 24 g of CM dissolved in 40 mL of sterile distilled water on d 0, 2, and 4; CEF (n = 47), subcutaneous injection of 6.6 mg/kg ceftiofur crystalline-free acid on d 0 and 3; and control (CON; n = 39), no treatment. For comparison, NMET cows (n = 180) were matched with metritic cows according to age at calving and calving date. Postdiagnosis, there was an effect of treatment and an interaction between treatment and time on rumination and activity. The interaction showed that CM had lesser rumination than CEF from d 1 to 11, d 18, and d 20; CM had lesser rumination than CON from d 2 to 8; and CEF was not different from CON. The interaction showed that CM had lesser activity than CON on d 2, from d 6 to 11, and d 13 to 14; CM was not different from CEF; and CEF had lesser activity than CON on d 8, 9, 13, and 14. Prediagnosis, cows in CM, CEF, and CON had lesser rumination and activity than cows in NMET. Postdiagnosis, cows in CM, CEF, and CON had lesser rumination than NMET from d 0 to 2 and had lesser activity than NMET from d 0 to 5. In summary, CM decreased rumination and activity compared with CON, which indicates a negative systemic effect of CM. This may be associated with exacerbated inflammation in the uterus. Additionally, metritic cows had decreased rumination and activity prediagnosis, which may allow for the use of AHMD for metritis diagnosis.
主要目的是描述用壳聚糖微粒（CM）或头孢噻呋（CEF）治疗的患子宫内膜炎初产奶牛的行为变化。次要目的是比较患子宫内膜炎奶牛与未患子宫内膜炎（NMET）奶牛的行为模式。在相对于产犊的-21至60天期间，为311头未产荷斯坦奶牛安装了颈部佩戴式自动健康监测设备（AHMD）。在产犊后21天内被诊断为子宫内膜炎（第0天）的奶牛，其特征为子宫排出水样、有恶臭、红棕色分泌物，被随机分配到CM组（n = 45），在第0、2和4天经子宫内注入溶解于40 mL无菌蒸馏水中的24 g CM；CEF组（n = 47），在第0和3天皮下注射6.6 mg/kg无结晶头孢噻呋酸；以及对照组（CON；n = 39），不进行治疗。为了进行比较，根据产犊年龄和产犊日期将NMET奶牛（n = 180）与患子宫内膜炎的奶牛进行匹配。诊断后，治疗对反刍和活动有影响，且治疗与时间之间存在交互作用。交互作用表明，从第1至11天、第18天和第20天，CM的反刍比CEF少；从第2至8天，CM的反刍比CON少；CEF与CON无差异。交互作用表明，在第2天、第6至11天以及第13至14天，CM的活动比CON少；CM与CEF无差异；在第8、9、13和14天，CEF的活动比CON少。诊断前，CM、CEF和CON组的奶牛比NMET组的奶牛反刍和活动少。诊断后，从第0至2天，CM、CEF和CON组的奶牛比NMET组的奶牛反刍少，从第0至5天，其活动比NMET组的奶牛少。总之，与CON相比，CM降低了反刍和活动，这表明CM有负面的全身效应。这可能与子宫内炎症加剧有关。此外，患子宫内膜炎的奶牛在诊断前反刍和活动减少，这可能使得AHMD可用于子宫内膜炎的诊断。
