Left-right asymmetry in oxidative stress sensing neurons in .

Perception of oxidative stress in nematodes involves specific neurons expressing antioxidant enzymes. Here, we carefully characterized GFP knock-in lines for peroxiredoxin PRDX-2 and thioredoxin TRX-1, and uncovered that left and right I2, PHA and ASJ neurons reproducibly express an asymmetric level of each enzyme. We observed that high-expressing neurons are in most cases associated with a particular side, indicating a directional rather than stochastic type of asymmetry. We propose that the biological relevance of this left-right asymmetry is to fine-tune H O or light sensing, which remains to be investigated.