Liu Aaron C, Harvey Melissa, Lee Alison, Hildebrand Kyla, Hoang Linda, Gantt Soren, Al-Rawahi Ghada N
Department of Paediatrics, University of British Columbia and BC Children's Hospital, Vancouver, British Columbia, Canada.
Department of Pathology and Laboratory Medicine, University of British Columbia and BC Centre for Disease Control Public Health Laboratory, Vancouver, British Columbia, Canada.
J Assoc Med Microbiol Infect Dis Can. 2021 Dec 3;6(4):333-336. doi: 10.3138/jammi-2021-0002. eCollection 2021 Dec.
is an obligate intracellular bacterium usually found as a commensal in the human oral cavity. Symptomatic infections with this organism are rare, but severe disease has been described in the setting of impaired humoral immunity. Here, we describe a case in which was identified from the joint fluid of a patient with septic arthritis, splenic lesions, and agammaglobulinemia. A 15-year-old boy was admitted to the hospital with fever, progressive left knee swelling, and pain. His medical history was significant for Burkitt's lymphoma, the treatment of which had included rituximab 6 years earlier. was identified in the synovial fluid using 16S ribosomal RNA gene sequencing. He was also found to be hypogammaglobulinemic, and imaging revealed multiple splenic lesions. He was treated with doxycycline and intravenous immunoglobulin, which resulted in complete resolution of his arthritis and other symptoms. species should be suspected in patients with humoral immunodeficiency and compatible findings.
是一种专性胞内细菌，通常作为共生菌存在于人类口腔中。该病原体的症状性感染很少见，但在体液免疫受损的情况下已有严重疾病的描述。在此，我们描述了一例从一名患有败血症性关节炎、脾脏病变和无丙种球蛋白血症患者的关节液中鉴定出该菌的病例。一名15岁男孩因发热、进行性左膝肿胀和疼痛入院。他的病史中有伯基特淋巴瘤，6年前的治疗包括使用利妥昔单抗。通过16S核糖体RNA基因测序在滑液中鉴定出该菌。还发现他存在低丙种球蛋白血症，影像学检查显示脾脏有多处病变。他接受了强力霉素和静脉注射免疫球蛋白治疗，关节炎和其他症状完全缓解。对于有体液免疫缺陷且有相符表现的患者，应怀疑该菌感染。
