Meng Yang, Xu Yishuang, Li Lu, Su Yu, Zhang Lu, Chen Changzheng, Yi Zuohuizi
Department of Ophthalmology, Renmin Hospital of Wuhan University, Wuhan, China.
Department of Ophthalmology, The Central Hospital of Wuhan, Wuhan, China.
Front Physiol. 2022 Oct 21;13:1008038. doi: 10.3389/fphys.2022.1008038. eCollection 2022.
To assess wide-field changes in choroidal thickness and choriocapillaris in eyes with central serous chorioretinopathy (CSC) compared with the fellow eyes and eyes from healthy individuals using wide-field swept-source (SS) OCT-Angiography (OCTA). A cross-sectional study in which 68 eyes from 34 individual patients affected by unilateral CSC and 32 eyes of 32 age- and sex-matched healthy subjects were evaluated. All subjects underwent wide-field SS-OCTA examination to quantify choroidal thickness and vascular density of the choriocapillaris. To assess the wide-field changes, we developed five 4-by-4 mm square regions located in the posterior pole and in the four quadrants of the peripheral retina (superotemporal, inferotemporal, superonasal, and inferonasal subfields, respectively). The choroidal thickness of eyes with CSC was greater than that of the fellow eyes in the central and inferonasal subfields ( < 0.001 for the central subfield and = 0.006 for the inferonasal subfield, respectively). Compared with the choroidal thickness of healthy eyes, that of patients with CSC were significantly greater in all the subfields ( < 0.05 for the fellow eyes and < 0.05 for eyes with CSC, respectively). Compared with that of healthy eyes, the vascular density of choriocapillaris in eyes of patients with CSC were significantly greater in the central and superotemporal subfields ( < 0.05 for the fellow eyes and < 0.05 for eyes with CSC, respectively). In the central region, the vascular density of choriocapillaris of the fellow eyes was greater than eyes with CSC ( = 0.023). CSC appears to be a bilateral disease with asymmetric manifestations. Local factors of the diseased eyes may play an important role in the development of CSC, during which dynamic and regional changes in the choriocapillaris may have happened. Wide-field swept-source OCTA provided a useful tool to study the pathogenesis of CSC.
利用广域扫频源（SS）光学相干断层扫描血管造影（OCTA），评估中心性浆液性脉络膜视网膜病变（CSC）患眼与对侧眼及健康个体眼睛相比脉络膜厚度和脉络膜毛细血管的广域变化。这是一项横断面研究，评估了34例单侧CSC患者的68只患眼以及32例年龄和性别匹配的健康受试者的32只眼睛。所有受试者均接受广域SS-OCTA检查，以量化脉络膜厚度和脉络膜毛细血管的血管密度。为评估广域变化，我们在黄斑后极及周边视网膜的四个象限（分别为颞上、颞下、鼻上和鼻下子区域）设置了五个4×4毫米的正方形区域。CSC患眼在中央和鼻下子区域的脉络膜厚度大于对侧眼（中央子区域P<0.001，鼻下子区域P = 0.006）。与健康眼的脉络膜厚度相比，CSC患者的患眼在所有子区域均显著增厚（对侧眼P<0.05，CSC患眼P<0.05）。与健康眼相比，CSC患者患眼脉络膜毛细血管的血管密度在中央和颞上子区域显著增加（对侧眼P<0.05，CSC患眼P<0.05）。在中央区域，对侧眼脉络膜毛细血管的血管密度大于CSC患眼（P = 0.023）。CSC似乎是一种具有不对称表现的双侧性疾病。患眼的局部因素可能在CSC的发生发展中起重要作用，在此过程中脉络膜毛细血管可能发生了动态和区域性变化。广域扫频源OCTA为研究CSC的发病机制提供了一个有用的工具。
