Zhang Liqun, Li Nan, Li Yuanhui, Zhang Tianjiao, Li Dai, Liu Yanru, Liu Xiang, Hao Wei
Adai Technology (Beijing) Co., Ltd., Beijing, China.
Department of Industrial Engineering, Tsinghua University, Beijing, China.
Front Psychiatry. 2022 Oct 19;13:1027695. doi: 10.3389/fpsyt.2022.1027695. eCollection 2022.
Methamphetamine is the most widely used illicit drug in China. Treating methamphetamine use disorder (MUD) is challenging due to the lack of effective pharmacotherapies. This study is an experimental study to investigate the efficacy of smartphone-based digital therapeutics in treating MUD at the community level. One hundred participants were recruited and randomized into a digital therapeutics (DTx) group ( = 52) and a treatment as usual (TAU) group ( = 48). The DTx group used a smartphone application to deliver cognitive behavioral therapy, approach bias modification, cognitive training, and contingency management for 8 weeks. The TAU group received counseling from social workers and professional psychotherapists. Cue-induced craving, cognitive functions, PHQ9, and GAD7 were measured at baseline and post-intervention. Wilcoxon tests were performed with bootstrap and multiply imputation to estimate the treatment effect size. The DTx group showed a significant reduction in drug craving [Wilcoxon effect size = -0.267, 95% CI = (-0.435, -0.099), = 0.002] and a significant improvement in cognitive function [Wilcoxon effect size = 0.220, 95% CI = (0.009, 0.432), = 0.041]. The DTx group had overall 1, 8, and 24-week attritions of 8%, 11.5%, and 38.5%, respectively. The study shows that Digital therapeutics is feasible and potentially beneficial as a complement to community substance use treatment programs.
甲基苯丙胺是中国使用最广泛的非法药物。由于缺乏有效的药物治疗方法，治疗甲基苯丙胺使用障碍（MUD）具有挑战性。本研究是一项实验性研究，旨在调查基于智能手机的数字疗法在社区层面治疗MUD的疗效。招募了100名参与者，并随机分为数字疗法（DTx）组（n = 52）和常规治疗（TAU）组（n = 48）。DTx组使用智能手机应用程序进行为期8周的认知行为疗法、趋近偏向矫正、认知训练和应急管理。TAU组接受了社会工作者和专业心理治疗师的咨询。在基线和干预后测量线索诱发的渴望、认知功能、PHQ9和GAD7。使用自助法和多重填补进行Wilcoxon检验，以估计治疗效果大小。DTx组的药物渴望显著降低[Wilcoxon效应大小=-0.267，95%CI=（-0.435，-0.099），P = 0.002]，认知功能显著改善[Wilcoxon效应大小=0.220，95%CI=（0.009，0.432），P = 0.041]。DTx组在1周、8周和24周的总体脱落率分别为8%、11.5%和38.5%。该研究表明，数字疗法作为社区药物使用治疗项目的补充是可行的，并且可能有益。
