Yuan Mei, Bedell Samantha, de Vrijer Barbra, Eastabrook Genevieve, Frisbee Jefferson C, Frisbee Stephanie J
Department of Pathology and Laboratory Medicine, Department of Obstetrics and Gynaecology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Canada.
Maternal-Fetal Medicine, Department of Obstetrics and Gynaecology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Canada.
Womens Health Rep (New Rochelle). 2022 Oct 26;3(1):850-866. doi: 10.1089/whr.2022.0062. eCollection 2022.
Although there is scientific literature supporting an association between depression and preeclampsia (PE), little is known about the underlying mechanistic pathways that may explain these observed associations. Thus, this study aimed to outline the relationship between depression and PE, and to highlight the underlying cardiovascular and metabolic risk factors that are common to both.
A scoping review of the literature was conducted in Medline, Scopus, and Web of Science.
From 706 articles initially identified, 23 articles met the inclusion criteria and were included in this review. Although some studies reported a positive association between PE and postpartum depressive symptoms, challenges comparing different methodologies, measurement instruments and when measurements were administered, and patient populations do not permit a decisive conclusion. In addition, very few studies addressed potential underlying mechanisms that may be contributing to observed associations; thus, a secondary search was conducted to identify cardiovascular and metabolic risk factors that are common to both depression and PE.
The cardiovascular and metabolic risk factors ( increased inflammation and oxidative stress and decreased vascular and endothelial function) common to both depression and PE suggest that these factors may contribute as underlying mechanisms in both conditions. These similarities underscore the importance to better understand these mechanisms so preventative and therapeutic strategies could be developed to improve maternal health.
尽管有科学文献支持抑郁症与先兆子痫（PE）之间存在关联，但对于可能解释这些观察到的关联的潜在机制途径知之甚少。因此，本研究旨在概述抑郁症与PE之间的关系，并强调两者共有的潜在心血管和代谢危险因素。
在Medline、Scopus和科学网对文献进行范围综述。
从最初确定的706篇文章中，有23篇文章符合纳入标准并被纳入本综述。尽管一些研究报告了PE与产后抑郁症状之间存在正相关，但由于比较不同方法、测量工具、测量时间以及患者群体存在挑战，因此无法得出决定性结论。此外，很少有研究探讨可能导致观察到的关联的潜在机制；因此，进行了二次检索以确定抑郁症和PE共有的心血管和代谢危险因素。
抑郁症和PE共有的心血管和代谢危险因素（炎症和氧化应激增加以及血管和内皮功能下降）表明，这些因素可能是两种疾病的潜在机制。这些相似之处凸显了更好地理解这些机制的重要性，以便能够制定预防和治疗策略来改善孕产妇健康。
