Giustini Nicholas P, Oh Hanna, Eaton Keith D
Division of Hematology, Department of Medicine, University of Washington, Seattle, Washington.
Department of Rehabilitation Medicine, University of Washington, Seattle, Washington.
JTO Clin Res Rep. 2022 Sep 30;3(11):100419. doi: 10.1016/j.jtocrr.2022.100419. eCollection 2022 Nov.
TRK inhibition can lead to on-target neurologic adverse events. Two cases illustrate the development of neuropathic arthropathy as a side effect of entrectinib. After starting entrectinib, both patients developed foot pain, swelling, and sensory changes with magnetic resonance imaging revealing marrow edema. Providers should have a low threshold to investigate foot pain or gait abnormalities thoroughly with magnetic resonance imaging and referral to specialists to aid in the diagnosis of neuropathic arthropathy, with consideration to transition to an alternative agent.
TRK抑制可导致靶向性神经系统不良事件。两例病例说明了神经关节病作为恩曲替尼副作用的发生情况。开始使用恩曲替尼后，两名患者均出现足部疼痛、肿胀和感觉改变，磁共振成像显示骨髓水肿。医疗人员对于彻底调查足部疼痛或步态异常应保持较低阈值，通过磁共振成像并转诊至专科医生以协助诊断神经关节病，并考虑换用其他药物。
