AliMohammadi Ali, Chezani-Sharahi Nahid, Hezaveh Zahra Asgari, Abbasi Elnaz, Shariati Aref, Ghaznavi-Rad Ehsanollah
Assistant Professor of Forensic Medicine and Toxicology, Arak University of Medical Sciences, Arak, Iran.
PhD student in Health Services Management, Arak University of Medical Sciences, Arak, Iran.
Vacunas. 2023 Jan-Mar;24(1):13-18. doi: 10.1016/j.vacun.2022.10.004. Epub 2022 Nov 1.
Infections caused by , especially carbapenem-resistant (CR) strains, pose important challenges in patients with COVID-19 infection. Therefore, in the present study, we investigated co-infection and antimicrobial resistance patterns, as well as the role of in the outcome of patients with COVID-19. Between February 2019 and January 2021, 141 patients with infections were detected from seven different hospitals (A to G) in Arak, Iran, and the antibacterial susceptibility pattern of these isolates was evaluated using disk diffusion and E-test methods. Forty-seven of these patients were co-infected with COVID-19. During the study, the data about the clinical course, demographic data, and the role of infections in the mortality rate of COVID-19 patients were collected. Hospitals A and B reported the most patients, with 53 (38%) and 47 (33%), respectively. Additionally, most cases (105 cases, 75%) were reported from surgical and general ICUs. Mechanical ventilators were detected as predisposing factors in 95 (67%) patients, and infection was detected in 20% of patients on the 10th day after intubation. All of the isolates were resistant to different classes of antibiotics, such as carbapenems. Notably, 33% (47 patients) were also positive for COVID-19, and 68% (32 patients) died due to the infection. Statistical analysis showed a significant role of co-infection in the mortality rate of COVID-19 patients (p-value 0.05). co-infection with is one of the most important challenges in COVID-19 patients. Our results showed that all isolated bacteria were CR and significantly increased mortality rates in COVID-19 patients.
由……引起的感染，尤其是耐碳青霉烯（CR）菌株，给COVID-19感染患者带来了重大挑战。因此，在本研究中，我们调查了合并感染情况和抗菌药物耐药模式，以及……在COVID-19患者预后中的作用。2019年2月至2021年1月期间，在伊朗阿拉克的七家不同医院（A至G）检测到141例……感染患者，并使用纸片扩散法和E-test法评估了这些分离株的抗菌药敏模式。其中47例患者合并感染了COVID-19。在研究期间，收集了有关临床病程、人口统计学数据以及……感染在COVID-19患者死亡率中的作用的数据。医院A和B报告的患者最多，分别为53例（38%）和47例（33%）。此外，大多数病例（105例，75%）来自外科和综合重症监护病房。在95例（67%）患者中检测到机械通气是易感因素，插管后第10天在20%的患者中检测到感染。所有……分离株均对不同类别的抗生素耐药，如碳青霉烯类。值得注意的是，33%（47例患者）的COVID-19检测也呈阳性，68%（32例患者）死于感染。统计分析表明……合并感染在COVID-19患者死亡率中具有显著作用（p值0.05）。……与……的合并感染是COVID-19患者面临的最重要挑战之一。我们的结果表明，所有分离出的细菌均为CR，且显著增加了COVID-19患者的死亡率。
