Krigman M R
Environ Health Perspect. 1978 Oct;26:117-20. doi: 10.1289/ehp.7826117.
The basis for utilizing altered morphology, i.e., pathology, in defining diseases of the nervous system is presented. The importance of recognizing the dynamics of pathologic processes is emphasized, particularly in understanding the pathogenesis of neural diseases. Demonstrative examples of the neuropathology of human heavy metal toxicity are presented. The limitations of descriptive pathology are considered, and the potentials of quantitative (morphometric) analysis for studying pathologic processes are introduced.
本文介绍了利用形态改变(即病理学)来定义神经系统疾病的依据。强调了认识病理过程动态变化的重要性,特别是在理解神经疾病发病机制方面。文中列举了人类重金属中毒神经病理学的实例。讨论了描述性病理学的局限性,并介绍了定量(形态计量)分析在研究病理过程中的潜力。