Department of Psychopathology of Child and Adolescent Development, Hospices Civils de Lyon, Lyon 1, France; UMR CNRS 8590 IHPST, Sorbonne University, Paris 1, France.
Univ Paris-Est-Créteil (UPEC), AP-HP, Hôpitaux Universitaires « H. Mondor », France; DMU IMPACT, INSERM, IMRB, Translational Neuropsychiatry, Fondation FondaMental, F-94010 Creteil, France.
Prog Neuropsychopharmacol Biol Psychiatry. 2023 Mar 8;121:110671. doi: 10.1016/j.pnpbp.2022.110671. Epub 2022 Oct 29.
Postpartum depression (PPD) is defined as a major depressive disorder (MDD) beginning after childbirth. Wide debates aim to better understand PPD's specificities compared with MDD. One of the keys in differentiating PPD from MDD is to systematically study scientific "Areas Of Interest" (AOIs) of these disorders.
In November 2021, we performed an extraction and textual computational analysis of associated terms for PPD and MDD, using the biomedical database PubMed. We performed an undirected lexical network analysis to map the 150 first terms in space. Then, we used an unsupervised machine learning technique to detect word patterns and automatically cluster AOIs with a topic-modeling analysis.
We identified 30,000 articles of the 554,724 articles for MDD and 15,642 articles for PPD. Four AOIs were detected in the MDD network: mood disorders and their treatments, risk factors, consequences and quality of life, and mental health and comorbidities. Five AOIs were detected in the PPD network: mood disorders and treatments, risk factors, consequences and child health, patient's background, and the challenges of screening.
Limitations are both methodological, in particular due to the qualitative interpretation of AOIs, and are also related to the difficult transferability of these research results to the clinical practice. The partial overlap between AOIs for MDD and for PPD suggest that the latter is a particular form of the former.
产后抑郁症（PPD）被定义为产后出现的重性抑郁障碍（MDD）。广泛的争论旨在更好地理解 PPD 与 MDD 的特殊性。将 PPD 与 MDD 区分开来的关键之一是系统地研究这些疾病的“关注领域”（AOIs）。
2021 年 11 月，我们使用生物医学数据库 PubMed 对 PPD 和 MDD 的相关术语进行了提取和文本计算分析。我们进行了无向词汇网络分析，以在空间中映射前 150 个术语。然后，我们使用无监督机器学习技术检测词模式，并使用主题建模分析自动聚类 AOI。
我们从 554724 篇 MDD 文章和 15642 篇 PPD 文章中确定了 30000 篇文章。在 MDD 网络中检测到 4 个 AOI：心境障碍及其治疗、风险因素、后果和生活质量以及心理健康和共病。在 PPD 网络中检测到 5 个 AOI：心境障碍和治疗、风险因素、后果和儿童健康、患者背景以及筛查的挑战。
局限性既有方法学上的，特别是由于对 AOI 的定性解释，也与这些研究结果难以转移到临床实践有关。MDD 和 PPD 的 AOI 部分重叠表明后者是前者的一种特殊形式。
