继发性草酸肾病与肾移植。
Secondary oxalate nephropathy and kidney transplantation.
机构信息
Division of Nephrology, Department of Medicine, University of Wisconsin School of Medicine and Public Health.
Department of Pharmacy, University of Wisconsin Hospital and Clinics, Madison, Wisconsin, USA.
出版信息
Curr Opin Organ Transplant. 2023 Feb 1;28(1):15-21. doi: 10.1097/MOT.0000000000001035. Epub 2022 Nov 7.
PURPOSE OF REVIEW
Secondary hyperoxaluria is associated with poor kidney allograft outcomes after the kidney transplant. Calcium oxalate (CaOx) deposition is common in early allograft biopsies leading to acute tubular necrosis and poor kidney allograft function. Though treatment options for secondary hyperoxaluria are limited, it is crucial to identify patients at increased risk of oxalate nephropathy after the transplant.
RECENT FINDINGS
Recent data suggest that significant changes in renal replacement therapies and dietary modifications in high-risk patients can prevent kidney allograft damage from the calcium oxalate deposition leading to improve allograft outcomes.
SUMMARY
The accurate and timely diagnosis of secondary oxalate nephropathy in kidney transplant recipients is paramount to preserving graft function in the long-term. This review will discuss the incidence, risk factors, prevention, and management of oxalate nephropathy in the kidney allograft.
目的综述
继发性高草酸尿症与肾移植后肾脏移植物的不良结局相关。草酸钙（CaOx）在早期移植活检中常见，导致急性肾小管坏死和肾脏移植物功能不良。尽管继发性高草酸尿症的治疗选择有限，但确定移植后草酸肾病风险增加的患者至关重要。
最新发现
最近的数据表明，高危患者的肾脏替代治疗和饮食改变的显著变化可以防止钙草酸沉积导致的肾脏移植物损伤，从而改善移植物结局。
总结
准确及时地诊断肾移植受者的继发性草酸肾病对于长期保存移植物功能至关重要。本文将讨论肾移植中草酸肾病的发生率、危险因素、预防和治疗。
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