Pan Qingqing, Luo Yaping, Cao Xinxin, Li Jian
Department of Hematology, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital; and, Beijing, China.
Clin Nucl Med. 2022 Dec 1;47(12):1118-1120. doi: 10.1097/RLU.0000000000004406. Epub 2022 Sep 6.
A 55-year-old man presented with chest tightness and lower-limb edema for 1 year. Laboratory and imaging examinations suggested cardiac amyloidosis. Both 18F-FDG and 68Ga-pentixafor PET/CT showed increased uptake in the myocardium of the left ventricle, whereas the bone marrow had diffusely mild uptake of 68Ga-pentixafor without bone destruction. 99mTc-MDP bone scintigraphy also detected extraosseous uptake in the heart, gut, kidneys, and soft tissue. The biopsy of the abdominal subcutaneous fat confirmed amyloid deposits, and the patient was finally diagnosed with primary systemic amyloidosis. This case demonstrated that cardiac amyloidosis might show increased 68Ga-pentixafor uptake in myocardium.
一名55岁男性因胸闷和下肢水肿1年就诊。实验室和影像学检查提示心脏淀粉样变性。18F-FDG和68Ga-喷替酸PET/CT均显示左心室心肌摄取增加，而骨髓对68Ga-喷替酸呈弥漫性轻度摄取，无骨质破坏。99mTc-MDP骨显像也检测到心脏、肠道、肾脏和软组织有骨外摄取。腹部皮下脂肪活检证实有淀粉样沉积物，该患者最终被诊断为原发性系统性淀粉样变性。该病例表明，心脏淀粉样变性可能表现为心肌对68Ga-喷替酸摄取增加。
